Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

Inclusion Criteria:

• No significant analgesic medication use before surgery: For this study, significantanalgesic medication use before surgery as use of prescriptions for opioid or NSAIDmedications in the past 30 days, or over-the-counter NSAID use on greater than 7 of 30 past days, as reported by the patient.

• One of three common low-risk surgical procedures: For this study, the three-commonlow-risk surgical procedures will include laparoscopic gallbladder removal, inguinalhernia repair, and breast lumpectomy.

Exclusion Criteria:

• Anticipated other surgery within 6 months or anticipated life expectancy of lessthan 6 months

• Patients with contraindications to NSAID drugs in the NSAID arm, opioid drugs in theOPIOID arm, or acetaminophen will be excluded. There are specific contraindicationsthat will be reviewed per protocol.