Renal Denervation in Patients With Chronic Heart Failure With Preserved Ejection Fraction

Inclusion Criteria:

1. signs or symptoms of heart failure;
2. normal or mildly abnormal systolic LV function (LVEF ≥ 50%);
3. evidence of diastolic LV dysfunction.
4. Individual should fulfill the diagnostic WHO criteria for hypertension: SBP > 140 mmHgand/or DBP > 90 mmHg, and is treated with at least 2 antihypertensive drugs. Thistreatment is expected to be maintained for at least 6 months. Using this regimen theblood pressure should be adequately controlled (< 140/90mmHg by 24 hour ambulatory BPmeasurement).
5. Individual is adhering to a stable drug regimen HFNEF, with no changes for a minimumof 2 weeks prior to enrollment, and which is expected to be maintained for at least 6months.

Exclusion Criteria:

1. Known secondary cause of hypertension
2. Anatomy not eligible for renal denervation
3. Systolic heart failure (LVEF < 50%)
4. Individual has an estimated glomerular filtration rate (eGFR) of < 30mL/min/1.73m2,using the MDRD calculation.
5. Individual has any serious medical condition, which in the opinion of theinvestigator, may adversely affect the safety and/or effectiveness of the participantor the study (i.e., patients with clinically significant peripheral vascular disease,abdominal aortic aneurysm, bleeding disorders such as thrombocytopenia, haemophilia,significant anaemia, or arrhythmias such as atrial fibrillation).
6. Individual is pregnant, nursing or planning to be pregnant.