Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)

Last updated: May 22, 2024
Sponsor: Duke University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Red Blood Cell Disorders

Sickle Cell Disease

Treatment

Gerofit Exercise Program

Clinical Study ID

NCT05714098
Pro00111833
  • Ages > 40
  • All Genders

Study Summary

The purpose of this study to assess the feasibility, acceptability, and safety of a personalized exercise training program adapted from Gerofit to improve physical health and quality of life for adults with SCD

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Have a diagnosis of sickle cell disease (any genotype) confirmed by hemoglobinelectrophoresis, high performance liquid chromatography, or genotyping

  • Understand and speak fluent English.

Exclusion

Exclusion Criteria:

  • Diagnosed with moderate or severe cognitive impairment based on ICD-10 codes orreport from their outpatient provider

  • Unable to self-consent

  • Wheelchair-bound

  • Successfully treated with hematopoietic stem cell transplantation for SCD

  • Have moderate to severe uncorrected visual or auditory impairment

  • Oxygen-dependent

  • Pregnant

  • Have severe avascular necrosis requiring an assist device

  • Unstable cardiac disease.

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Gerofit Exercise Program
Phase:
Study Start date:
March 27, 2023
Estimated Completion Date:
December 30, 2028

Study Description

The purpose of this study is to adapt and pilot the Gerofit personalized exercise intervention for older adults with sickle cell disease (age ≥ 40 years). The Sickle Cell Disease Functional Assessment (SCD-FA) will be performed at steady state at baseline and every 3 months to track progress. Endpoints include feasibility, acceptability, and safety. All participants will be interviewed to identify barriers and facilitators to exercise and how to better optimize the exercise intervention.

Connect with a study center

  • Duke University

    Durham, North Carolina 27710
    United States

    Active - Recruiting

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