Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA

Inclusion Criteria:

1. Participant is 5 through 18 years of age (inclusive) at screening.

2. Regarding informed consent and compliance:

3. If 5 through 6 years of age, the participant's guardian is willing and able tounderstand and provide informed consent and comply with study protocol.

4. If 7 through 17 years of age, the participant is willing and able to signassent and comply with study protocol, and the participant's guardian iswilling and able to understand and provide informed consent and comply withstudy protocol.

5. If 18 years of age, the participant is willing and able to understand andprovide informed consent and comply with study protocol.

6. The participant has a Juvenile Idiopathic Arthritis (JIA) diagnosis meetingInternational League of Associations for Rheumatology (ILAR) classification criteriawith one of the following subtypes:

7. rheumatoid-factor negative polyarthritis

8. rheumatoid-factor positive polyarthritis

9. persistent oligoarthritis

10. extended oligoarthritis

11. psoriatic arthritis

12. enthesitis-related arthritis

13. systemic arthritis

14. The participant has >=3 joints with active arthritis at screening

15. If the participant is receiving therapy for JIA at screening, that therapy is stablefor the time period outlined below and is expected to remain stable for the durationof the study: a. stable dose for at least 1 week prior to screening: i. Oral steroids, <= 0.2 mg/kg/day with a maximum 10 mg/day dose b. stable dose for at least 2 weeks prior to screening: i. NSAIDs c. stable dose for at least 8 weeks prior to screening: i. adalimumab ii. anakinra iii. canakinumab iv. certolizumab pegol v. etanercept vi. golimumab vii. infliximab viii. leflunomide ix. methotrexate x. tocilizumab d. stable dose for at least 12 weeks prior to screening: i. abatacept

16. If a female of child-bearing potential, the participant has a negative urinepregnancy test at screening

17. If of reproductive potential, must agree to abstinence or effective methods of birthcontrol for the duration of the study

Exclusion Criteria:

1. Other than NSAIDs or intra-articular injections, participant has been treated forJIA with lack of efficacy with:

2. More than 2 different classes of therapies, or

3. More than 3 medications in total

4. Participant has received high-dose steroids (>=0.2 mg/kg/day) within the 28 daysprior to screening.

5. Participant has had active systemic disease (fever, systemic rash) within the 3months prior to screening including any of the following lab manifestations atscreening:

6. Ferritin >1000 ng/mL

7. White blood cell (WBC) ≥15,000/mm^3

8. Participant has had an active acute systemic infection within 2 weeks of screening.involving fever (100.4⁰F or higher) for more than 24 hours, requirement for systemicantibiotics or antivirals, GI symptoms lasting 48 hours or more, or the need to holdsecond line medications for JIA (methotrexate or biologic).

9. Participant has a history of arrhythmia.

10. Participant has been diagnosed with postural orthostatic tachycardia syndrome (POTS).

11. Participant has received an intra-articular cortisone injection within the 28 daysprior to screening.

12. Participant has received treatment with an investigational drug or device during the 28 days prior to screening or within five half-lives of the investigational drugprior to screening/baseline, whichever is the greater length of time.

13. Participant has received chronic treatment with an anti-cholinergic medication,including over the counter medications.

14. Participant has received treatment with rituximab:

15. Within one year of screening

16. At any time previously without documented B cell repletion

17. Participant has a comorbid disease that has required treatment with corticosteroidswithin the past year.

18. Participant has an implantable electronic device such as a pacemaker, defibrillator,hearing aid, cochlear implant, insulin pump or deep brain stimulator.

19. Participant has used cutaneous vagus nerve stimulation within 12 weeks prior toscreening.

20. Participant has received a live attenuated viral vaccine within 28 days prior toscreening or is expected to receive one during the study.

21. Participant has any condition which, in the opinion of the investigator, wouldjeopardize the participant's safety following exposure to a study intervention.

22. Participant has any past or current medical problems or findings from a physicalexamination or laboratory testing that are not listed above but which, in theopinion of the investigator, may pose additional risks from participation in thestudy, may interfere with the participant's ability to comply with studyrequirements, or may impact the quality or interpretation of the data obtained fromthe study.