A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

Inclusion Criteria:

• Adults 18 years or older

• Newly diagnosed glioblastoma (Within 2 months of initial diagnosis byhistopathology)

• Not started standard of care chemotherapy and/or radiation therapy for glioblastoma

• Karnofsky Performance Status (KPS) ≥ 70

• Ability to read, write and understand either English OR Spanish

• Written informed consent obtained from subject and ability for subject to complywith the requirements of the study.

Exclusion Criteria:

• Patients with recurrent glioblastoma

• Genetic disorders that affect lipid metabolism. Including but not limited topyruvate carboxylase deficiency, porphyria, primary carnitine deficiency, carnitinepalmitoyltransferase I or II deficiency, carnitine translocase deficiency,beta-oxidation defects

• Inability to wean steroids below 8mg dexamethasone / day or equivalent

• Body Mass Index (BMI) < 21kg/m2, unless the site Principal Investigator deems safe

• Currently pregnant or nursing

• Patients receiving other experimental therapy Note: Off-label therapy use ispermitted

• Comorbidities that in the opinion of the investigator limit the patient's ability tocomplete the study

• Food preferences incompatible with keto diet

• Using a pacemaker, implantable cardiac defibrillator, neurostimulator, cochlearimplants (removable hearing aids permitted), or other electronic medical equipment,unless the site Principal Investigator deems safe

• Inability to participant in standard of care MRIs