The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS Technology

Inclusion Criteria: Inclusion criteria for control group:

1. Healthy control participants who could provide a recent depression screening report,and confirm they have not any cardiovascular, respiratory, digestive, urinary,hematological, endocrine, or neurological disease;
2. 15 ≤ age ≤22 years, male or female;
3. Participants have clear consciousness and could communicate with others normally;
4. Participants could understand the full study protocol and have high adherence. Writteninformed consent is signed by adult participants themselves，and the minor participantsis signed by a guardian;
5. Participants should be right-handed; Inclusion criteria for observation group:
6. MDD patients should meet the diagnostic criteria of the International Classificationof Diseases 11th Edition (ICD-11) diagnostic criteria for MDD;
7. 15≤ age ≤22, male or female;
8. Participants have clear consciousness and could communicate with others normally;
9. Participants could understand the full study protocol and have high adherence. Writteninformed consent is signed by adult participants themselves，and the minor participantsis signed by a guardian;
10. Not taking antidepressants or antipsychotic drugs for at least 4 weeks beforeenrollment;
11. Participants should be right-handed;

Exclusion Criteria: Exclusion criteria for control group:

1. Participants with serious primary diseases of cardiovascular diseases, liver diseases,kidney diseases, urinary diseases, and hematological diseases;
2. Participants have an illness, alcohol dependence, or a history of drug abuse;
3. Pregnant or lactating participants;
4. Participants with intellectual disabilities who can't cooperate with the questionnairesurvey;
5. Participants with bleeding tendency, skin disease, allergic constitution, and allergicto adhesive tape;
6. The test site of participants has scars, hyperpigmentation, red and swollen;
7. Participants are participating in other trials; Exclusion criteria for observation group:
8. Participants with serious primary diseases of cardiovascular, respiratory, digestive,urinary, hematological, endocrine, neurological disease, and other serious primarydiseases, and the disease cannot be effectively controlled clinically;
9. MDD caused by organic mental disorders, schizophrenia, bipolar disorder, psychoactivesubstances, and non-addictive substances;
10. Participants with suicidal tendencies;
11. Pregnant or lactating participants;
12. Participants with intellectual disabilities who cannot cooperate with thequestionnaire survey;
13. Participants with bleeding tendency, skin disease, allergic constitution, and allergicto adhesive tape;
14. The skin at the test site of participants has scars, hyperpigmentation, red andswollen;
15. Participants are participating in other trials;