Retrospective Review of Esophageal Cancer at MSKCC

Last updated: May 8, 2025
Sponsor: Memorial Sloan Kettering Cancer Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Esophageal Cancer

Digestive System Neoplasms

Esophageal Disorders

Treatment

Esophagectomy

Clinical Study ID

NCT05706558
16-1631
  • Ages > 18
  • All Genders

Study Summary

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cellcarcinoma (ESCC) undergoing esophagectomy

  • Pathologic staged T3 tumors (pT3)

Exclusion

Exclusion Criteria:

  • Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)

  • Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma insitu without tumor invasion,

  • Patients undergoing salvage esophagectomy

  • Evidence of distant metastatic disease

  • Patients with a positive proximal or distal margin

Study Design

Total Participants: 4000
Treatment Group(s): 1
Primary Treatment: Esophagectomy
Phase:
Study Start date:
December 13, 2016
Estimated Completion Date:
February 28, 2026

Connect with a study center

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    New York, New York 10065
    United States

    Active - Recruiting

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