Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis

Last updated: January 11, 2026
Sponsor: Misr International University
Overall Status: Completed

Phase

N/A

Condition

Dermatomyositis (Connective Tissue Disease)

Rheumatoid Arthritis

Arthritis And Arthritic Pain

Treatment

Non surgical periodontal treatment

Clinical Study ID

NCT05706493
PER 3312007
  • Ages > 18
  • All Genders

Study Summary

the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Rheumatoid patients fulfilling the ACR criteria for the classification of RA

  • 18 years

  • Both genders

  • Presence of at least 8 teeth

Exclusion

Exclusion Criteria:

  • Smoking

  • Diabetes Mellitus

  • Pregnant females

  • Patients who had undergone periodontal treatment within last 3 months

  • Antibiotic therapy during last 3 months

  • Other autoimmune diseases

Study Design

Total Participants: 36
Treatment Group(s): 1
Primary Treatment: Non surgical periodontal treatment
Phase:
Study Start date:
March 01, 2024
Estimated Completion Date:
February 01, 2025

Study Description

the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics.

The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients Materials and Methods: a total of 40 participants suffering from periodontitis and rheumatoid arthritis will be referred from the Badr Hospital (Faculty of Medicine, Helwan University) to Misr international university's dental clinic complex. Gingival crevicular fluid (GCF) samples will be collected from the patients before performing periodontal therapy (baseline). Assessment of ACPAs will be quantified using enzyme-linked immunoassay (ELISA) as the primary outcome at baseline and after 3 months. Assessment of 2ry outcomes includes clinical periodontal and RA parameters at baseline and after 3 months.

Connect with a study center

  • Faculty of oral and dental medicine, Misr international university

    Cairo, 12345
    Egypt

    Site Not Available

  • Faculty of oral and dental medicine, Misr international university

    Cairo 360630, 12345
    Egypt

    Site Not Available

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