Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis

Last updated: May 14, 2025
Sponsor: Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Overall Status: Active - Enrolling

Phase

N/A

Condition

Scar Tissue

Multiple Sclerosis

Memory Loss

Treatment

Optical coherence tomography (OCT)

Visual processing speed test

Microperimetry

Clinical Study ID

NCT05706220
22-PI045
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This project aims to analyze ocular motility problems, visual processing speed and microperimetry, and their relationship with consolidated retinal structural biomarkers (optical coherence tomography, OCT) in patients with Multiple Sclerosis w/w reading complaints comparing with healthy subjects.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of Multiple Sclerosis

  • Best distant corrected visual acuity equal or greater than 0.7 (decimal scale).Glasses or soft contact lenses users.

  • Best close corrected visual acuity equal to or greater than 20/30 (Snellenscale).Glasses or soft contact lenses users.

Exclusion

Exclusion Criteria:

  • Patients with a history of acute optic neuritis (ON) and/or who experienced anepisode of ON <6 months prior to the study, to avoid potential interference ofpapilledema with accurate peripapillary RNFL thickness measurements.

  • Patients with other retinal and optic nerve diseases, advanced cataracts accordingto the international Lens Opacities Classification System III (LOCS III) (opacitiesgreater than C2N2)

  • Patients with other ophthalmological diseases that could affect central visualacuity

  • Subjects with high refractive error (+ - 6 diopters).

  • Subjects with other demyelinating disorders (neuromyelitis optica or acutedisseminated encephalomyelitis).

Study Design

Total Participants: 120
Treatment Group(s): 4
Primary Treatment: Optical coherence tomography (OCT)
Phase:
Study Start date:
June 13, 2022
Estimated Completion Date:
December 31, 2025

Study Description

Anamnesis, ophthalmological medical history including difficulties in reading with appropriate glasses.

The following protocol will be applied:

  • Comprehensive eye examination

  • Stereopsis

  • Primary gaze position

  • Cover test: far and near

  • Vergence and version eye movements

  • Presence of nystagmus

  • Far and near best corrected visual acuity, with updated refraction

    -.Pupillary light reflex

  • Biomicroscopy of the anterior pole

  • Intraocular pressure

  • Recording of eye movements during two standardized tests: International Reading Speed Texts test (IReST®) and Developmental Eye Movement Test (DEM™) with Tobii™ Pro Nano hardware package eye-tracking system and Tobii™ Pro Lab - full edition software.

  • Visual processing speed

  • Microperimetry

  • Optical coherence tomography

  • Eye fundus

  • Patients with a history of clinical optic neuritis will additionally undergo contrast sensitivity tests, the Farnsworth® test (Farnsworth test 28 Hue x 100) and normal monocular perimetry using the standard Swedish Interactive Thresholding Algorithm (SITA-central 24-2) perimeter test. Humphrey® (Humphrey visual field analyser) and other tests at the discretion of the investigator.

Connect with a study center

  • IOBA - Universidad de Valladolid

    Valladolid, 47011
    Spain

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.