Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)

Inclusion Criteria:

1. ≥18 years of age

2. Presentation to a Duke outpatient clinic with heart failure requiring IV diuretics,as per clinician judgement

3. Able to provide signed informed consent

4. Successful completion of EuroQOL-5 dimensions survey

Exclusion Criteria:

1. Managing clinician without equipoise for initial outpatient treatment strategyversus initial hospitalization-based treatment strategy for heart failure, anddecline to accept randomization.

2. Patient without equipoise for initial outpatient treatment strategy versus initialhospitalization-based treatment strategy for heart failure, and decline to acceptrandomization.

3. History of left ventricular assist device or heart transplantation

4. End-stage kidney disease requiring chronic dialysis therapy

5. New diagnosis of heart failure

6. Pregnant or breast-feeding

7. Fever >101.0 degrees Fahrenheit at screening

8. Any other condition that in the judgment of the investigator would jeopardize thepatient's compliance with the study protocol