Application of "Heidelberg Triangle" Dissection in Pancreatoduodenectomy and Distal Pancreatectomy

Last updated: July 28, 2023
Sponsor: Fudan University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pancreatitis

Pancreatic Disorders

Pancreatic Cancer

Treatment

TRIANGLE operation

Clinical Study ID

NCT05703581
Huadong Hospital to Fudan
  • Ages 18-90
  • All Genders

Study Summary

Aim of the study :

To evaluate the effect and safety of "Heidelberg Triangle" dissection (TRIANGLE operation) combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary cancer .

Methods :

Patients who underwent pancreatoduodenectomy or Distal Pancreatectomy between 01 September 2016 and 30 December 2022 will be included in this retrospective analysis. 3D reconstruction is performed with preoperative enhanced CT, then the region of "Heidelberg Triangle" is categorized . The operation is completed by the same operation team. According to the operation mode, patients were divided into TRIANGLE group and non-TRIANGLE group and And followed up until recurrence, death or missed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients diagnosed by preoperative imaging and auxiliary examination as resectable orborderline resectable pancreatic malignant tumor or periampullary carcinoma whounderwent pancreatoduodenectomy or distal pancreatectomy, with or without TRIANGLEoperation.
  2. Patients who have no serious abnormalities of blood system, heart and lung functionand immune deficiency and can tolerate surgery.
  3. Be able to comply with the research visit plan and other program requirements

Exclusion

Exclusion Criteria:

  1. Patients accompanied by other systemic malignancies.
  2. Central nervous system disease, mental disease, unstable angina pectoris, congestiveheart failure, serious arrhythmia and other uncontrollable serious diseases, unable totolerate surgery.
  3. Pregnant and lactating women.
  4. Any condition that may impair the safety of patients or the integrity of researchdata, including serious medical risk factors, medical conditions, and laboratoryabnormalities.

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: TRIANGLE operation
Phase:
Study Start date:
March 01, 2023
Estimated Completion Date:
February 01, 2024

Study Description

The "Heidelberg Triangle" is an anatomical area composed of Common hepatic artery (CHA), superior mesenteric artery (SMA) and superior mesenteric vein (SMV).

This area is considered to be the common site of recurrence after pancreatic surgery.

Recent studies have shown that TRIANGLE operation can improve the state of the cutting edge and has potential value in improving the prognosis. However, the data on recurrence and survival rate of pancreatic cancer and periampullary cancer after TRIANGLE operation are insufficient.

The aim of the present study is to evaluate the effect and safety of "Heidelberg Triangle" dissection combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary cancer .

Connect with a study center

  • Huadong Hospital affiliated to Fudan University

    Shanghai,
    China

    Active - Recruiting

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