Personalized Mobile Cognitive Behavioral Therapy Application

Last updated: April 28, 2025
Sponsor: Weill Medical College of Cornell University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anxiety Disorders

Bipolar Disorder

Depression

Treatment

General MAYA Mobile App

Personalized MAYA Mobile App

Clinical Study ID

NCT05699525
21-09023953
  • Ages 18-25
  • All Genders

Study Summary

This study aims to compare the effectiveness of a standard mobile iPhone cognitive behavioral therapy program to a personalized mobile iPhone cognitive behavioral therapy program that introduces new skills over a shorter period of time. Participants will use the Maya app for two days per week, at least 20 minutes per day, for six weeks. Assessments will include a weekly check in with a member of the research team, questionnaires, and optional magnetic resonance imaging (MRI) and electroencephalographic (EEG) recordings at the beginning and end of the 6-week intervention. The investigators think that that the less burdensome personalized program will be just as effective at improving symptoms of anxiety and depression as the general program.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age between 18 and 25 years.

  • Primary diagnosis of an anxiety, depressive, or bipolar disorder as determined by ascore of 4 or greater on the Clinical Severity Rating of the Anxiety DisordersInterview Schedule (ADIS).

  • If an individual is diagnosed with bipolar disorder, they must be currently euthymicor experiencing a depressive episode.

  • Access to an Apple iPhone

Exclusion

Exclusion Criteria:

  • History of neurologic disorder that may affect the neural systems of interest orparticipant's ability to participate

  • Lifetime diagnosis of a psychotic disorder.

  • Current hypomanic or manic episode.

  • Currently in cognitive behavior therapy.

  • Change in dose of a psychiatric medication in the past 12 weeks.

  • Initiation of psychotherapy in the past 12 weeks.

  • Intent or plan to attempt suicide.

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: General MAYA Mobile App
Phase:
Study Start date:
August 02, 2024
Estimated Completion Date:
July 31, 2027

Study Description

Growing evidence suggests a need for anxiety and mood interventions that can be disseminated easily to adolescents and young adults. The goal of this study is to optimize a mobile application that teaches well-established, research-supported psychotherapeutic techniques to adolescents and young adults who are experiencing symptoms of anxiety, depression, and/or bipolar disorder. The study aims to compare the efficacy of a personalized mobile cognitive behavioral therapy program to a more general mobile cognitive behavioral therapy program.

Study participants will randomly receive one of two versions of Maya, a mobile cognitive behavior therapy (CBT) app for adolescents and young adults: either a standard version that includes a variety of skills typically used in CBT, or a personalized version with skills matched to the participant's symptom profile. In contrast to the general condition, which may introduce new material over all six weeks of the intervention, all new material in the personalized condition will be introduced within the first four weeks. The remaining two weeks in the personalized condition will consist of practicing previously learned skills. Participants will use the Maya app for two days per week, at least 20 minutes per day for six weeks and will complete assessments at baseline, week 4, week 6 (end of intervention), and a follow-up assessment at week 12. Participants may also choose to complete an optional magnetic resonance imaging (MRI) and/or electroencephalographic (EEG) recording at the baseline and end of intervention (week 6).

Connect with a study center

  • Weill Cornell Medical College

    New York, New York 10065
    United States

    Active - Recruiting

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