Daily Vinegar Ingestion and Metabolic Health

Last updated: January 30, 2024
Sponsor: Arizona State University
Overall Status: Completed

Phase

N/A

Condition

Metabolic Disorders

Inflammation

Diabetes Prevention

Treatment

Vinegar pill

Liquid vinegar

Clinical Study ID

NCT05698381
STUDY00017204
  • Ages 18-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to determine if vinegar ingestion promotes beneficial changes to metabolic health parameters in healthy, overweight adults.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • healthy
  • non-smoker
  • free of chronic disease by self-report
  • able to speak, read, and understand English
  • able to consent.
  • BMI ≥ 25 and ≤ 35

Exclusion

Exclusion Criteria:

  • adherence to specific diets for weight loss
  • vegetarian
  • report GERD or regular heartburn
  • unwilling to consume vinegar daily for 4 weeks
  • pregnant or lactating women
  • recreational drug use, alcohol intake above recommendations (1 drink/day for women, 2drinks/day for men - or none)
  • competitive level physical training (e.g., physical activity above recommendations asset by the Physical Activity Guidelines for Americans)
  • scoring 1 or higher on question 9 of the PHQ-9 questionnaire.

Study Design

Total Participants: 36
Treatment Group(s): 2
Primary Treatment: Vinegar pill
Phase:
Study Start date:
February 01, 2023
Estimated Completion Date:
August 15, 2023

Study Description

Recent research, in animal and human subjects, suggests that vinegar intake is inversely associated with insulin resistance, mood states and depression, inflammation, and other disease parameters. The study will be conducted as a randomized controlled trial in overweight adults to further examine these relationships and possible mechanisms. Although the mechanisms are not known, research suggests that changes in the gut microbiome, a response to the ingestion of the postbiotic acetic acid, may factor into the beneficial effects of vinegar ingestion. Through analyses of blood, changes in key blood metabolites associated with mood states (e.g., gamma-aminobutyric acid) as well as markers of gut health (e.g., LPS binding protein) and inflammation (e.g., CRP) will be assessed. Additionally mood state will be assessed using validated measures and determine risk for metabolic syndrome, a cluster of risk factors associated with many chronic conditions. It is hypothesized that vinegar ingestion will promote beneficial changes to these health parameters.

Connect with a study center

  • 850 PBC

    Phoenix, Arizona 85004
    United States

    Site Not Available

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