Parkinson's disease(PD) is a distinctive clinical disorder with a multifactorial range of
etiology and symptoms. This neurodegenerative disease is spreading at exponent rates. It can
impact individuals enormously. As a degenerative disease, its progression can span decades.
The disease has profound repercussions for caregivers and is also a socio-economic burden for
society SAFFRON Saffron is a spice obtained from the stigmas of the Crocus sativus L flower,
grown extensively in Iran and other parts of the world, including Greece and India. According
to current data, saffron cultivation and usage date back approximately 3000 years, although
the oldest records of this plant date back to the Assyrian era.
Saffron is a perennial plant that grows to a height of 10 to 30 cm. Numerous leaves branch
out from the bulb's center, culminating in two to three blooms. The color is determined by
the amount of lycopene and carotenoid contained inside a three-branched stigma stigma.
Saffron contains 5% fat, 5% minerals, 10% moisture , 12% protein, 63% sugars and 5% crude
fiber. Stigmas contain around 150 volatile chemicals, including terpenes, and alcohol, along
with their esters. Three important bioactive components in Saffron are crocin, safranal, and
picrocrocin, which are responsible for Saffron's taste, unique color r. Saffron's bitter
flavor is created by picrocrocin, which eventually transforms into safranal. Additionally,
lycopene, zeaxanthin, carotene, vitamins including thiamine and riboflavin are active
components Saffron contains about 150 compounds, however the most physiologically active are
two carotenoids called crocin and crocetin .Both of these compounds have been evaluated
pharmacokinetically in animal and human research. According to pharmacokinetic studies Crocin
is not accessible in the bloodstream as it is after oral intake but converted to crocetin in
the colon. Additionally, it may cross the blood-brain barrier and enter the central nervous
system through passive transcellular diffusion, making it beneficial in neurodegenerative
illnesses.
CHAMOMILE Matricaria recutita chamomilla is an annual plant native to Europe and Asia with
branching, tall, and smooth stems. Apigenin, apigenin-7-O-glucoside, luteolin, and
luteolin-7-O-glucoside, terpene bisabolol ,caffeic acid, farnesene, chamazulene, chlorogenic
acid flavonoids (apigenin, quercetin, , patuletin and luteolin), and coumarin are the
chemical components found in this plant.
Pharmacological activities German chamomile is beneficial for treating stomachaches, IBS, and
sleeplessness. It has anti-inflammatory, antibacterial, and relaxing properties.
Additionally, it has acaricidal effects. Several animal studies have revealed that this herb
has neuroprotective,anxiolytic, antimutagenic, cholesterol-lowering, wound healing, and
antidiabetic effects. Chamomile was shown to have weak antibacterial and antioxidant
capabilities, but substantial antiplatelet and anticarcinoma activities in in vitro
experiments.
Rationale of the study :
In various preclinical studies role of saffron and chamomile is found effective in treating
Parkinson disease. Their neuroprotective and antioxidant effects are also widely known.
Although, efficacy of this combination in treating Parkinson disease as a clinical trial is
yet to be analyzed .Therefore, this clinical trial is designed to determine the effects of
saffron and chamomile as combination in compared to approved pharmacotherapy
Aim :
To study the effects of Saffron and Chamomile in the treatment of with reference to
psychometric biochemical , and Insilco measures.
HYPOTHESIS Null Hypothesis There is no beneficial effects of Saffron and chamomile in the
treatment of Parkinson disease Alternative Hypothesis Saffron and chamomile have efficacy in
the treatment of Parkinson disease
AIM & OBJECTIVES
- To evaluate and compare :
clinical efficacy of saffron and chamomile in the management of Parkinson disease.
the effects of saffron and chamomile on plasma biomarkers in the management of Parkinson
disease.
the antioxidant effects of saffron and chamomile in the management of Parkinson disease.
