Expression of microRNA-133a and microRNA-208b in Acute Myocardial Infarction

Last updated: January 18, 2023
Sponsor: Islamia University of Bahawalpur
Overall Status: Completed

Phase

N/A

Condition

Heart Disease

Coronary Artery Disease

Hypercholesterolemia

Treatment

N/A

Clinical Study ID

NCT05692752
UCCM/2022/EGT/01
  • Ages 35-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Cardiac-enriched micro-RNAs (miRNAs), micro RNA 208b and 133a(MiR-208b, MiR-133a)) corresponds to the health and disorders of the cardiovascular system. An intron of the cardiac myosin heavy chain gene MYH7 encodes miR-208b. It is found on chromosome 14 in humans. Identify new diagnostic biomarkers based on miRNAs, researchers examine the expression of miR-133a and 208b at various time points (04 hours, 08 hours, 12 hours, 24 hours, 48 hours) following the development of the infarct and compared it to the traditional myocardial infarction biomarkers cardiac troponine (cTnl) and Creatine kinase-MB (CK-MB).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients diagnosed with ST-Elevated Myocardial Infarction will be identified at theCoronary Care Unit at Ain-shams University hospital
  2. Acute episode of Myocardial Infarction
  3. With No history of previous Myocardial Infarction Treatment

Exclusion

Exclusion Criteria:

  1. Patients not diagnosed with ST-Elevated Myocardial Infarction and healthy at theCoronary Care Unit at Ain-shams 2. University hospital
  2. Previously Known patients of Myocardial infacrtion
  3. Previous medication

Study Design

Total Participants: 10
Study Start date:
December 28, 2022
Estimated Completion Date:
January 14, 2023

Study Description

The 98% of human genes are non-coding RNA, which is further divided into long non-coding RNA (lncRNA, > 200 bp) and short non-coding RNA (200 bp, including microRNA (miRNA) and circular RNA). More than 2000 human miRNAs have been discovered, and it seems that they regulate around 60% of human genes.Through a number of pathways, miRNAs control the development, re-modelling, and regeneration of the heart as well as endothelial function, vasculo-genesis, and neoangiogenesis. 30% of the genes in the human genome are regulated by about 1000 miRNAs. Endogenous miRNAs are 19-22 nucleotide single-stranded RNA molecules that frequently target the 3' untranslated regions (3'-UTR) of mRNAs to regulate gene expression at the post-transcriptional level in physiological processes, disease development, and conditions like cancer, autoimmune and inflammatory diseases, neuro-degenerative diseases, and cardiovascular diseases. Cardiac-enriched miRNAs, MiR-208 in health and disorders of the cardiovascular system are investigated.

Identify new diagnostic biomarkers based on miRNAs, researchers examine the expression of miR-133a and 208b at various time points (04 hours, 08 hours, 12 hours, 24 hours, 48 hours) following the development of the infarct and compared it to the traditional myocardial infarction biomarkers cTnl and CK-MB.

Connect with a study center

  • Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance Al Tagamoa Al Khames

    Cairo, 11835
    Egypt

    Site Not Available

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