Effect of Magnesium Supplementation on Elevated Systolic Blood Pressure

Last updated: June 1, 2025
Sponsor: Brigham and Women's Hospital
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

N/A

Treatment

placebo

magnesium glycinate supplement

Clinical Study ID

NCT05690464
2022P002101
  • Ages 30-74
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to assess whether 480 mg/day magnesium glycinate supplementation for 12 weeks lowers blood pressure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Self-report of systolic blood pressure 125-159 mmHg

  • Measured seated systolic blood pressure 130-159 mmHg at screening visit

  • Body mass index less than 40 kg/m2

  • Total magnesium intake from supplements of no more than 100 mg/day

  • Willing to maintain current diet and supplement use patterns during the 12-weekintervention period

Exclusion

Exclusion Criteria:

  • Measured seated diastolic blood pressure 100 mmHg or greater at screening visit

  • Antacid or laxative use 4 times/week or more within the past 3 months

  • History of cardiovascular disease (myocardial infarction, stroke, revascularization [coronary artery bypass graft or percutaneous transluminal coronary angioplasty], orangina pectoris)

  • History of invasive cancer diagnosed within the last 5 years (non-melanoma skincancer permitted)

  • History of type 1 or 2 diabetes

  • History of renal disease

  • History of kidney failure

  • History of dialysis

  • History of pancreatitis

  • History of inflammatory bowel disease

  • History of hypermagnesemia

  • Women who are pregnant, nursing, or intend to become pregnant during the period oftreatment

  • Plan to relocate out of Boston area within the next year

  • Unwillingness and/or inability to swallow 4 pills per day

  • Inability to provide written informed consent

Study Design

Total Participants: 120
Treatment Group(s): 2
Primary Treatment: placebo
Phase:
Study Start date:
January 17, 2023
Estimated Completion Date:
October 31, 2025

Study Description

This clinical trial will test whether a magnesium glycinate supplement (480 mg/day) taken for 12 weeks lowers blood pressure in 120 adults aged 30-74 who have a systolic blood pressure of 130-154 mmHg.

Eligibility to participate in the trial will be determined by a 2-stage screening process. Interested participants will complete a pre-screening form online. If eligibility criteria are met, the potential participants will be scheduled for an in-person screening clinic visit. At the visit, eligible participants will be reminded about the study details and potential risks and will be given the opportunity to sign the Informed Consent. Consented participants will be assigned by chance (like a coin toss) to daily magnesium or to placebo. Participants will take 4 study capsules per day (2 capsules in the morning and 2 capsules in the evening) for 12 weeks.

Assessments at the screening visit include seated blood pressure; pulse; weight, height, waist and hip circumference measurements; fasting blood and urine collection; and health and diet questionnaires. Participants will return for a clinic visit at 12 weeks to assess these measures.

Connect with a study center

  • Brigham and Women's Hospital

    Boston, Massachusetts 02215
    United States

    Site Not Available

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