A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney Disease

Inclusion Criteria:

1. Sign the informed consent voluntarily, and fully understand and comply with therelevant procedures of the test;

2. Age of ≥ 18 years old, gender is not limited;

3. Patients with chronic kidney disease (CKD) stage G1~G3 with albuminuria,requirements:

4. eGFR ≥ 30 mL/min/1.73m^2 at Screening based on the CKD-EPI equation (2009).

5. RAS inhibitor therapy (ACEi and/or ARB) has been administered for at least 12weeks and the maximally tolerated dose has been stable for at least 4 weeksprior to randomization; If an SGLT2i is prescribed, the dose must be stable forat least 8 weeks prior to randomization.

6. Cohort 1: Diagnosed with type 2 diabetes mellitus and receiving at least onehypoglycemic agent in the 12 months prior to randomization; In accordance withthe diagnostic criteria of DKD, urine albumin to creatinine ratio (UACR) ≥300mg/g before randomization.

7. Cohort 2: Biopsy-proven IgA nephropathy; Urine protein-creatinine ratio (UPCR) ≥0.75 g/g or urine protein excretion rate ≥ 1.0 g/24h before randomization.

8. Laboratory parameters meet the following criteria:

9. Serum albumin ≥30 g/L;

10. Hemoglobin value ≥90 g/L; Platelet ≥80×10^9/L;

11. Brain natriuretic peptide (BNP) ≤ 200 pg/mL or N-terminal pro-B-typenatriuretic peptide (NT-proBNP) ≤ 600 pg/mL;

12. Blood potassium ≤ 5.5 mmol/L;

13. Systolic blood pressure (SBP) ≤140 mmHg; Diastolic blood pressure (DBP) ≤90mmHg;

14. Hemoglobin A1c (HbA1c) ≤ 10% (cohort 1)/Hemoglobin A1c (HbA1c) < 6.5% (cohort 2);

15. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2×ULN;Total bilirubin ≤1.5ULN;

16. All participants should follow protocol defined contraceptives procedures.

Exclusion Criteria:

1. Women who were pregnant or breastfeeding; A WOCBP who has a positive blood pregnancytest prior to randomization;

2. Patients who are allergic to or are allergic to any component of the study drug (SC0062 capsules);

3. Systemic use of corticosteroids or immunosuppressants for more than 2 weeks within 3months prior to randomization; with exceptions as follows: Topical orintra-articular, intranasal, and inhaled glucocorticoids; on stable doses ofhydroxychloroquine for at least 8 weeks.

4. Type 1 diabetes or other specific types of diabetes;

5. Secondary IgA nephropathy;

6. Clinical suspicion of rapidly progressive glomerulonephritis (RPGN);

7. Diagnosed with nephrotic syndrome;

8. Have a history of pulmonary hypertension (WHO Group 1), idiopathic pulmonaryfibrosis or any lung disease requiring oxygen therapy (e.g., chronic obstructivepulmonary disease, emphysema, pulmonary edema, etc.);

9. Subjects who had received endothelin receptor antagonist in the past;

10. History of moderate or severe edema, non-traumatic facial edema, or myxoid edemawithin the 6 months prior to randomization;

11. History of orthostatic hypotension within 6 months prior to randomization;

12. History of clinically significant cirrhosis;

13. History of heart failure NYHA Class III~IV; exacerbation heart failure or acutecoronary syndrome within 6 months prior to randomization;

14. History of renal transplantation or other organ transplantation;

15. Hypothyroidism (except subclinical hypothyroidism or stable hypothyroidism afterhormone replacement therapy);

16. Patients who have the potential to interfere with oral drug absorption, such assubtotal gastrectomy, clinically severe gastrointestinal disease, or certain typesof bariatric surgery, such as gastric bypass surgery, that do not involve simplyseparating the stomach into a separate chamber, such as gastric banding surgery;

17. Use of potent CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin,phenobarbital, St. John's Burt) and potent CYP3A4 inhibitors (e.g., itraconazole,ketoconazole, voriconazole, clarithromycin, telomycin, nefazodone, ritonavir,saquinavir) within 1 month before randomization;

18. Active hepatitis B; active hepatitis C; active syphilis; positive HIV serumreaction.

19. Malignancy within the past 5 years (Except for treated basal cell carcinoma of theskin, effectively resected squamous cell carcinoma of the skin, colon polyps, orcervical cancer in situ that do not require ongoing treatment);

20. Alcohol or drug abuse or dependence, or a history of psychological disorder;

21. Participants participated in clinical trials of other investigational drugs ormedical devices within 3 months prior to randomization;

22. Any other clinically significant clinical condition, or medical history mayinterfere with the subject's safety, study evaluation, and/or study procedures perthe judgment by the investigator;

23. The investigator believes that the subject has any other reasons for not beingeligible to participate in this clinical study.