Phase
Condition
Female Hormonal Deficiencies/abnormalities
Heavy Bleeding / Heavy Periods
Dysfunctional Uterine Bleeding
Treatment
N/AClinical Study ID
Ages 12-40 Female
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Female
Age 12-40 years
Presence of HMB
Evidence of severe iron-deficiency anemia (hemoglobin level of < 8 g/dL)
Exclusion
Exclusion Criteria:
Inability or unwillingness of research participant or legal guardian/representativeto give written informed consent.
Current use of anticoagulant and antiplatelet medications
Currently pregnant
Medical conditions that could cause HMB but are not necessarily a bleeding disorder,including, but not limited to:
Uncontrolled hypertension
Documented uterine structural abnormality
Insulin-dependent diabetes mellitus
Chronic kidney disease
Chronic liver disease
Thyroid disease
Documented peripheral arterial disease, venous or arterial vascular events inthe past
A structural pathology that would explain the HMB
Presence of a bleeding disorder indicated by prothrombin time, activated partialthromboplastin time, fibrinogen, and von Willebrand factor activity, antigen andfactor VIII
Persistent thrombocytopenia as defined by a platelet count of <150,000/uL
If the participant answers "yes" to any of the following questions, they areineligible:
Could the patient have a known connective tissue disorder?
Family history of sudden death
Family history/personal history of uterine rupture or bowel perforation
Family history/personal history of arterial rupture
Family history/personal history of aneurysm
Family history/personal history of an established EDS diagnosis based ongenetic evaluation
Study Design
Study Description
Connect with a study center
St. Jude Children's Research Hospital
Memphis, Tennessee 38105
United StatesActive - Recruiting
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