Stroke-induced Myocardial Dysfunction: Role of GDF-15 (SMOG-15) Clinical Work Package

Last updated: January 24, 2025
Sponsor: Centre Hospitalier Universitaire Dijon
Overall Status: Active - Recruiting

Phase

N/A

Condition

Thrombosis

Cardiac Ischemia

Stroke

Treatment

Collection of clinical and radiological data

transthoracic echocardiography

72-hour continuous Holter-ECG recording

Clinical Study ID

NCT05683873
BEJOT ANR 2019
  • Ages > 18
  • All Genders

Study Summary

The aim of this study is to analyze the relationship between the blood biomarker GDF-15 and heart damage after stroke.

It is being conducted in France, in the Neurology Department of the Dijon University Hospital (Burgundy). The research is interventional because a biological blood test will be performed, as well as a heart rhythm recording and several cardiac echograms during the hospitalization of the participants and during the follow-up consultation scheduled 4 to 6 months after the stroke.

A total of 130 stroke patients will participate in this study.

Participation includes 4 visits:

  • Inclusion visit (within 24 hours of the first stroke symptoms)

  • visit 1 (within 24 to 72 hours of stroke)

  • visit 2 (within 48 hours of visit 1)

  • Visit 3 (approximately 4-6 months post-stroke)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult with acute symptomatic cerebral infarction documented by brain imaging onadmission (cerebral angioscan or cerebral MRI)

  • Whose first symptoms appeared within 24 hours before inclusion

  • Whose consent to participate in this study was obtained from the patient or a closerelative.

Exclusion

Exclusion Criteria:

  • Person with a history of symptomatic stroke, either ischemic or hemorrhagic

  • Anyone with a history of heart disease including: atrial fibrillation or flutter (known or discovered on admission), chronic heart failure, pacemaker, defibrillator,or other cardiac devices

  • Person with acute heart failure, suspected infective endocarditis, STEMI, orconcurrent pulmonary embolism

  • A person who is not a member or beneficiary of a social security system

  • Person deprived of liberty

  • Person subject to a legal protection measure (curatorship, guardianship)

  • Person subject to a legal protection measure

  • Pregnant, parturient or breastfeeding woman

Study Design

Total Participants: 130
Treatment Group(s): 7
Primary Treatment: Collection of clinical and radiological data
Phase:
Study Start date:
February 13, 2023
Estimated Completion Date:
August 31, 2027

Connect with a study center

  • Chu Dijon Bourgogne

    Dijon, 21000
    France

    Active - Recruiting

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