OMAR Opioid Use Disorder

Last updated: September 8, 2026
Sponsor: Yale University
Overall Status: Active - Recruiting

Phase

1

Condition

Opioid Use Disorder

Stimulant Use Disorder

Treatment

[11C]OMAR

Clinical Study ID

NCT05683184
2000033525
2K12DA000167-31
1R21DA052864-01A1
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid receptor 1 (CB1R) availability.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Able to provide informed consent

  • Male and female 18 years and older

  • DSM-5 diagnosis of opioid use disorder (for OUD group)

  • Physically healthy i.e., no clinically unstable medical conditions

  • Written informed consent and have capacity to consent and comply with studyprocedures

Exclusion

Exclusion Criteria:

  • Current neuro-psychiatric illness or severe systemic disease (opioid use disorder ispermitted in the OUD group).

  • Presence of ferromagnetic metal in the body or heart pacemaker

  • Have had exposure to ionizing radiation that in combination with the study tracerwould result in a cumulative exposure that exceeds recommended exposure limits

  • Are claustrophobic

  • Hematocrit values lower than 30

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: [11C]OMAR
Phase: 1
Study Start date:
March 10, 2023
Estimated Completion Date:
December 15, 2027

Study Description

The investigators will image brain cannabinoid receptors using Positron Emission Tomography (PET) imaging and the radioligand [11C] OMAR, in healthy individuals and individuals diagnosed with opioid use disorder. Research participants may complete screening, MRI, PET scan and follow up visits.

Connect with a study center

  • Connecticut Mental Health Center, Clinical Neuroscience Research Unit

    New Haven, Connecticut 06519
    United States

    Active - Recruiting

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