Follow up of Moderate Aortic Regurge After Mitral Valve Replacement

Last updated: January 10, 2023
Sponsor: Assiut University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Collagen Vascular Diseases

Musculoskeletal Diseases

Connective Tissue Diseases

Treatment

N/A

Clinical Study ID

NCT05680610
Assuit unimed
  • All Genders

Study Summary

Aim of the study is to follow of of moderate aortic regurge after mitral valve replacement to figure out if the aortic regurge has been improved or it is getting worse

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients underwent mitral valve replacement for rheumatic heart disease and havingmoderate aortic valve regurge GRADE 2 in assuit university hospitals

Exclusion

Exclusion Criteria:

  • non rhumatic heart disease ,severe aortic regurge ,moderately severe aortic regurge ,combined ischmic and valvular heart diseaese

Study Design

Total Participants: 100
Study Start date:
August 01, 2022
Estimated Completion Date:
October 01, 2024

Study Description

A considerable proportion of patients who require mitral valve replacement present with a coexisting pathology of the aortic valve (AV). Rheumatic fever remains the leading cause for combined disease (1) Early series found that one-third of rheumatic hearts exhibited involvement of both mitral and aortic valve. The rate increased to 99% when the follow-up period was extended to 20 years The treatment of choice in cases in which one of the valves is moderately affected is questionable. Because combined aortic and mitral valve replacement is usually associated with higher risk and poorer long-term survival than replacement of either of the two valves alone (2) In patients with moderate aortic regurgitation who undergo mitral valve surgery). according to 2021 ESC/EACTS Guidelines, the decision to treat the aortic valve is controversial, as data show that progression of moderate aortic regurgitation is very slow in patients without aortic dilation (3) in contrast , In 2020 AHA guidelines recommended concomitant aortic valve replacement for moderate aortic regurgitation in patients undergoing surgery for ascending aorta, coronary artery bypass grafting (CABG),or mitral valve surgery (4-10) Because of this is a point of conflict we aim in this study to evaluate the saftey to leave moderate aortic regurge without intertvention as regarding operative time ,postoperative morbidity and mortality and progression of aortic valve regurge.

Connect with a study center

  • Faculty of medicine

    Assiut, Assuit 71125
    Egypt

    Active - Recruiting

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