Deep Brain Therapy With Low-intensity Ultrasound for Generalized Chronic Pain

Inclusion Criteria:

1. Age 18-65, any gender

2. Primary diagnosis of generalized chronic pain or widespread chronic pain.

3. Moderate-to-severe chronic pain lasting at least 2 months

4. Stated willingness to comply with all study procedures and avoid changes to currenttreatments (medications, physical therapy, cognitive behavioral therapy) for theduration of the study

5. For females of reproductive potential: negative pregnancy test or use of highlyeffective contraception for at least 1 month prior to baseline; agreement to usesuch a method throughout the study

6. Capacity to provide informed consent; provision of a signed and dated consent form

Exclusion Criteria:

1. History of serious brain injury or other neurologic disorder

2. Poorly managed general medical condition

3. Pregnant or breast feeding

4. Implanted device in the head or neck

5. MRI intolerance or contraindication

6. Brain stimulation (e.g., VNS, TMS) in the past month

7. Lifetime history of a serious suicide attempt (Hooley et al., 2014)

8. Clinically inappropriate for participation in the study as determined by the studyteam