Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section

Last updated: November 28, 2024
Sponsor: Assiut University
Overall Status: Active - Recruiting

Phase

1/2

Condition

Gastroparesis

Bowel Dysfunction

Ileus

Treatment

0.9%sodium chloride

Dexamethasone

Clinical Study ID

NCT05654649
post-spinal paralytic ileus
  • Ages 18-40
  • Female

Study Summary

Postoperative ileus is a perplexing problem for clinical surgeons. It occurs not only after abdominal surgery but also after any surgery that requires general anesthesia. Postoperative ileus is defined as the dysfunction of gastrointestinal motility after surgery, characterized by a decrease in, or stagnation of, intestinal peristalsis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • •All participants will sign an informed consent prior to inclusion in the study.

  • All patients 18-40 years of full-term singleton pregnancy (37-41 weeks).,

  • American Society of Anaesthesiologists (ASA) classification class I and IIscheduled.

  • for elective or semi-elective surgery (category 3 and 4 Caesarean sections).

  • All patients under spinal anesthesia for a Single baby pregnancy of more than 32 weeks will be included in this study.

Exclusion

Exclusion Criteria:

  • will be patients' height < 150 or > 180 cm.

  • Body mass index (BMI) >35 kg m-2.

  • Contraindication or refusal to undergo regional anesthesia.

  • any cardiovascular disease including arrhythmias and severe stenotic valvular heartdisease.any renal or hepatic diseased patients.

Study Design

Total Participants: 90
Treatment Group(s): 2
Primary Treatment: 0.9%sodium chloride
Phase: 1/2
Study Start date:
December 01, 2022
Estimated Completion Date:
December 31, 2024

Study Description

Common clinical manifestations include abdominal pain, abdominal distention, nausea, vomiting, delayed flatus, delayed defecation, and inability to consume orally. Postoperative ileus is an uncomfortable experience, enhances the possibility of postoperative complications, prolongs hospital stay, and increases the economic burden. Postoperative gastrointestinal function recovery is of great concern. There is currently an urgent need to improve postoperative recovery of gastrointestinal function. The mechanism of Postoperative ileus varies, including autonomic regulation, inflammatory response, gastrointestinal hormones, and postoperative use of opioid drugs. Surgical gut damage destroys the intestinal barrier, stimulates the sympathetic and parasympathetic nervous systems, and enhances the release of inflammatory factors. These factors precipitate the occurrence of Postoperative ileus. The current use of laparoscopic techniques can reduce incision size and surgical trauma, enabling careful manipulation.

Connect with a study center

  • woman health hospital , Assiut university

    Assiut, 71515
    Egypt

    Active - Recruiting

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