A Study of APS03118 in Advanced Solid Tumors Harboring RET Mutations or Fusions

Inclusion Criteria:

1. Male or female patients aged 18 years or older

2. Have histological or cytological confirmation of unresectable locally advanced ormetastatic solid tumors harboring oncogenic RET mutations or fusions confirmed byNGS. Site may identify patients with a RET-mutated or RET-fusion solid tumor beforethe formal screening.

3. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.

4. Resolution of all toxic effects of prior therapies to Grade 1 or below according toNCI CTCAE version 5.0 (except alopecia or Grade 2 neuropathy);

5. Patients with asymptomatic brain metastases if they have been previously treated,demonstrated no progression at least for 1 months before Screening, are asymptomaticand have had no requirement for steroids or enzyme inducing anticonvulsants in thelast 14 days before Screening

6. Adequate organ function

Exclusion Criteria:

1. Have a locally advanced solid tumor that is a candidate for curative surgerytreatment through radical surgery and/or radiotherapy.

2. Have an active fungal, bacterial, and/or active untreated viral infection

3. The patient has a serious pre-existing medical condition(s)

4. Have received or will receive a COVID-19 vaccine within 1 month before the firstdose of APS03118.