Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation in Low-risk Patients

Last updated: December 5, 2022
Sponsor: Zhang Xiaofeng,MD
Overall Status: Completed

Phase

N/A

Condition

Colorectal Cancer

Colon Cancer

Treatment

N/A

Clinical Study ID

NCT05648318
20211206301
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Adequate quality of bowel preparation(BP) is essential for colonoscopy. In recently, Kang suggested that for low-risk patients, single dose of 2L PEG is an effective regimen for bowel preparation.However, due to the poor palatability, there still more than 30% patients with 2L regimen experienced nausea or vomiting in our center.

Oral lactulose is a treatment for constipation. Several studies have compared the effectiveness between use PEG and lactulose for colonoscopy preparation in average-risk patients. However, the data in low-risk patients is vacant. The objective of current study was to compared the effectiveness of bowel preparation and patient tolerance using lactulose and 2L PEG regimen in low-risk patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients over 18 years old and with low-risk were eligible. Patients were consideredas low risk if they did not meet any of the following risk factors: age>70 years old,body mass index (BMI)>25Kg/m2, constipation, Parkinson's disease, diabetes, history ofstroke or spinal cord injury, use of tricyclic antidepressant or narcotics.

Exclusion

Exclusion Criteria:

  • (1) history of colorectal resection; (2) Known or suspected colonic stricture orobstructing tumor; (3) Known or suspected colonic perforation; (4) toxic colitis ormegacolon; (5) use of prokinetic agents or purgatives within 7 days; (6) hemodynamicinstability; (7) pregnancy or lactation; (8) inability to provide informed consent.

Study Design

Total Participants: 255
Study Start date:
January 08, 2022
Estimated Completion Date:
September 12, 2022

Connect with a study center

  • Hangzhou first people's Hospital

    Hangzhou, Zhejiang 310000
    China

    Site Not Available

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