A Noninterventional, Single-Center Feasibility Study to Evaluate Measures of Heart Failure Risk

Key Inclusion Criteria:

• Cohort 2: Confirmed medical history of LVH based on American College of Cardiology (ACC)/American Heart Association (AHA) guidelines and NYHA Class I at screening

• Cohort 3: Confirmed medical history of HF consistent with current ACC/AHA guidelinesand NYHA Class I at screening

• Cohort 4: Confirmed medical history of HCM consistent with ACC/AHA guidelines andNYHA Class I or II at screening

Key Exclusion Criteria:

• Active neurological disorder, such as uncontrolled seizure disorder.

• Current diagnosis of cancer or other known acute chronic infection, such ashepatitis B or hepatitis C, by medical history or an active infection requiringinterventional therapy at screening.

• Shortness of breath, fatigue, heart palpitations, pain, or other limitations ofphysical activity