Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis

Phase

N/A

Condition

Pancreatitis

Treatment

N/A

Clinical Study ID

NCT05638555

1983542-1

All Genders

Study Summary

This study aims to compare NS and LR in terms of outcomes in patients with acute pancreatitis while addressing the current methodological issues with available meta-analyses on the topic. Such comparison combined with bias adjustment will assist with identifying the optimal fluid rehydration therapy in acute pancreatitis, since most of the available data is conflicted around the topic. A database search will be conducted to identify studies comparing normal saline and ringer's lactate. Existing meta-analyses will be assessed. The results will be discussed in the light of their strengths and limitations and then any deficiencies will be addressed through a new synthesis as a final step of this umbrella review. The primary outcome will be SIRS at 24 hours. OR and 95% confidence intervals will be generated using the quality effects model. Heterogeneity will be evaluated using the I2 statistic. Publication bias will be assessed using the Doi Plot.

Eligibility Criteria

Inclusion

Inclusion Criteria:

RCTs and observational studies that compared NS vs LR in AP patients.
Studies reviewed must report data as effect estimates or provide raw data sufficientto calculate effect estimates.

Exclusion

Exclusion Criteria:

Studies involving animal studies, pediatric patient populations, and cell lines willbe excluded. All studies will be reviewed in full form by each author to determine eligibility. In caseof disagreement, determination of inclusion will be reached via consensus.

Study Design

August 15, 2023

June 01, 2024

Connect with a study center

Suhail Doi
Doha, 2713
Qatar
Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.