Treatment of Ano-perineal Fistulas Resistant to Surgical Treatment with a Gel and Plug of Wharton's Jelly

Inclusion Criteria:

• Male or female, aged 18 to 65 years.

• Patient with a single anal fistula resistant after at least one surgical treatment.Fistula may be related to Crohn's disease.

• Patient with an upper transsphincteric or lower transsphincteric fistula.

• Patient presenting fistula with or without intersphincteric diverticula.

• Fistula effectively drained with a seton.

• Informed and consenting patient.

• Patient who is a member or a beneficiary of a national health insurance plan.

Exclusion Criteria:

• Pregnant or breastfeeding woman or woman of childbearing age without effectivecontraception.

• Patients who have had more than one failed obstruction technique.

• Patient with more than one internal orifice.

• Patient with an MRI proven abscess.

• Patient with an uncontrolled infection.

• Patient with a contraindication to anesthesia.

• Person deprived of liberty by a judicial or administrative decision.

• Adult subjected to a legal protection measure or unable to express his / herconsent.