In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma

Last updated: July 30, 2024
Sponsor: Heather Wachtel
Overall Status: Active - Recruiting

Phase

1

Condition

Neuroendocrine Carcinoma

Treatment

[18F]FluorThanatrace ([18F]FTT)

Clinical Study ID

NCT05636540
UPCC 10322
851463
  • Ages > 18
  • All Genders

Study Summary

This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment.

A pre-treatment 18F-FluorThanatrace ([18F]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic therapy.

PET/CT imaging will be used to evaluate PARP-1 expression in sites of pheochromocytoma or paraganglioma using the investigational radiotracer [18F]FTT. This is an observational study in that [18F]FTT PET/CT will not be used to direct treatment decisions. While patients and referring physicians will not be blinded to the [18F]FTT PET/CT results, treatment decisions will be made by the treating physicians based upon clinical criteria.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Participants will be ≥ 18 years of age.

  2. Clinical diagnosis of pheochromocytoma or paraganglioma based on biochemical andimaging studies At least one lesion identified on standard of care imaging (e.g. CT,MRI, FDG or 68-Gallium dotatate, other PET/CT or MIBG).

  3. Standard of care germline genetic testing performed for clinical purposes orparticipant's consent for germline genetic testing for research purposes.

  4. Participants must be informed of the investigational nature of this study and bewilling to provide written informed consent and participate in this study inaccordance with institutional and federal guidelines prior to study-specificprocedures.

Exclusion

Exclusion Criteria:

  1. Inability to tolerate imaging procedures in the opinion of an investigator ortreating physician.

  2. Females who are pregnant or breastfeeding will not be eligible for this study; aurine pregnancy test will be performed in women of child-bearing potential prior toFTT injection.

  3. Any current medical condition, illness, or disorder as assessed by medical recordreview and/or self-reported that is considered by a physician investigator to be acondition that could compromise participant safety or successful participation inthe study.

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: [18F]FluorThanatrace ([18F]FTT)
Phase: 1
Study Start date:
July 01, 2023
Estimated Completion Date:
December 31, 2025

Study Description

Up to 30 patients who will undergo approximately 60 minutes of dynamic scanning head to thigh starting at approximately the same time as the injection, this will be followed by a second head to thigh scan [starting at approximately 90 minutes post injection. PET/CT imaging sessions will include an injection of ≤ 12 mCi of [18F]FTT intravenously (approximate range for most studies is anticipated to be 8-12 mCi).

If surgery is performed according to standard of care tissue will be processed for both clinical and research use, if the subject has consented for use of tissue. Data will be collected to evaluate uptake of [18F]FTT in pheochromocytoma and paraganglioma and compare with PARP-1 activity and other experimental assays in tissue from biopsy and surgery, when available.

All evaluable patients may undergo surgery or systemic therapy following the [18F]FTT PET/CT scan. Up to 10 patients undergoing systemic therapy may undergo a second (optional) scan that will be performed approximately 1-21 days after therapy has started. The second scan is obtained to evaluate whether the initiation of systemic therapy alters [18F]FTT uptake. As this is a pilot study, only a limited number of patients are sought for the second scan.

Connect with a study center

  • Abramson Cancer Center of the University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

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