CAR-DC Vaccine and ICIs in Local Advanced/Metastatic Solid Tumors

Inclusion Criteria:

1. Age 18-75 (inclusive).
2. ECOG performance status ≤2 and Estimated life expectancy of more than 3 months.
3. Local advanced/metastatic solid tumors confirmed by histopathology or cytology withdocumentation of tumor EphA2 positive (≥20%) and KRAS mutation (G12V or G12D or G12C)within 6 months prior to screening. The second malignancy is allowed.
4. No clinical response to standard frontline therapy, or no standard therapy exists.Patients who have declined standard therapy or have no access to standard therapy maybe enrolled and the reasons for lack of access need to be documented. Previoustreatment with anti-PD-1/PD-L1 antibodies or anti-CTLA4 antibody are allowed,regardless of the level of PD-1/PD-L1 expression, dMMR and TMB.
5. At least one measurable lesion at baseline per RECIST version 1.1.
6. Adequate organ function as defined by the following criteria: ANC ≥1000 cells/μL;Platelet count ≥80,000/μL; Hemoglobin ≥8.0 g/dL; Serum AST and serum ALT, ≤3.0 x ULN (≤5 x ULN for patients with liver metastases); Total serum bilirubin ≤3.0 x ULN);Serum creatinine ≤2 x ULN or creatinine clearance of ≥45 mL/min.
7. Willing to undergo either excised or large-needle lymph node or tissue biopsy, orprovide formalin-fixed paraffin-embedded (FFPE) tumor tissue block or freshly cutunstained slides.
8. Willing to complete all scheduled visits and assessments at the institutionadministering therapy.
9. Able to read, understand and provide written informed consent.

Exclusion Criteria:

1. Having KRAS (G12V or G12D or G12C) germline mutation.
2. Active central nervous system disease involvement (but allow patients with prior brainmetastases treated at least 4 weeks prior to enrollment that are clinically stable anddo not require intervention), or prior history of NCI CTCAE Grade ≥3 drug-related CNStoxicity.
3. Prior organ allograft transplantations or allogeneic hematopoietic stem celltransplantation.
4. Evidence of active uncontrolled viral, bacterial, or systemic fungal infection.
5. Known positive test result for human immunodeficiency virus (HIV) or acquired immunedeficiency syndrome (AIDS).
6. Active infection of hepatitis B virus (HBV), or hepatitis C virus (HCV).
7. Patients with history (within the last 5 years) or risk of autoimmune disease who haveimmunosuppressive medications or immunosuppressive doses of systemic corticosteroids (>10 mg/day prednisone or equivalent) within 28 days prior to enrollment. However,patients who received a short course of corticosteroids (eg, premedication prior toantibody drug) will be eligible for study entry.
8. Major trauma or major surgery within 4 weeks prior to enrollment.
9. Previous treatment involving KRAS mutant (G12V or G12D or G12C) and EphA2.
10. Systemic chemotherapy and other intervene within 2 weeks prior to vaccination.
11. Being participating or withdrew any other trials within 4 weeks.
12. Any serious underlying medical (eg, pulmonary, renal, hepatic, gastrointestinal, orneurological) or psychiatric condition or any issue that would limit compliance withstudy requirements.
13. Vaccination within 30 days of study enrollment.
14. Pregnant, lactating, or breastfeeding females.
15. Researchers believe that other reasons are not suitable for clinical trials.