Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Last updated: May 15, 2025
Sponsor: Thomas Jefferson University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Prostate Cancer, Early, Recurrent

Prostate Disorders

Prostate Cancer

Treatment

Training and Education

Educational Intervention

Discussion

Clinical Study ID

NCT05627219
22C.423
JT 22046
  • Ages > 18
  • Male
  • Accepts Healthy Volunteers

Study Summary

This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). While genetic testing has become central to prostate cancer care, African American men are less likely seek testing due to lack of awareness, cultural beliefs, financial limitations, fear of discrimination, and mistrust in the healthcare system. A network of peer genetic coaches may help address barriers, beliefs, and needs of African American men in the community and provide navigation to increase engagement in genetic testing.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • AIM 1: Are 18 years old or older

  • AIM 1: Are able to read and speak English comfortably

  • AIM 1: Men who have experience with both prostate cancer (PCA) and geneticcounseling and testing will be a priority for training, as well as men who haveconsiderable peer education or navigation experience

  • AIM 2: Are 18 years old or older

  • AIM 2: Are African American

  • AIM 2: Are able to read and speak English comfortably

  • AIM 2: Men who meet any one of the following criteria: (1) metastatic prostatecancer; (2) prostate cancer with high-risk features (T3 or higher, Gleason 8 orhigher, node positive disease); (3) with or without a diagnosis of prostate cancerwith strong family history (2 or more first-degree or second-degree relatives) withprostate cancer (particularly metastatic prostate cancer or died from prostatecancer), breast cancer, ovarian cancer, pancreatic cancer, colorectal cancer,uterine cancer, renal cancer, urothelial cancer, or upper bowel cancer

Exclusion

Exclusion Criteria:

  • Patients that do not meet the inclusion criteria

  • Children under the age of 18

  • Anyone who has trouble understanding the consent or with significant anxietydetected during the consent process

Study Design

Total Participants: 30
Treatment Group(s): 3
Primary Treatment: Training and Education
Phase:
Study Start date:
June 03, 2024
Estimated Completion Date:
April 29, 2026

Study Description

PRIMARY OBJECTIVES:

I. Identify and train 6 African American (AA) men as peer genetic coaches (PGCs) for the Extending Prostate Genetic Awareness, Navigation, and Delivery (EXPAND) Network. (Train peer genetic coaches) II. Conduct a feasibility study of peer genetic coaching. (Provide individual coaching)

SECONDARY OBJECTIVE:

I. Patient-related outcomes will include change in decisional conflict for genetic counseling, acceptability/attitude toward genetic counseling and testing, and change of genetics knowledge.

OUTLINE:

AIM 1: Peer genetic coaches undergo training and education on study.

AIM 2: Patients receive an educational booklet and attend a discussion with a peer genetic coach on study.

Connect with a study center

  • Sidney Kimmel Cancer Center at Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Active - Recruiting

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