Multiple-dose Trial to Determine the Clinical Bioequivalence Between Tavapadon Tablets in Participants With Parkinson's Disease

Inclusion Criteria:

1. Body mass index of 17.5 to 38.0 kilograms per square meter (kg/m^2), inclusive, andtotal body weight >50 kg (110 pounds [lb]) at Screening.
2. Participants with a diagnosis of Parkinson's disease (PD) that is consistent with theUnited Kingdom (UK) Parkinson's Disease Society Brain Bank diagnostic criteria.
3. Must be modified Hoehn & Yahr Stage I-III inclusive.
4. Must be on a stable dose of L-Dopa of at least 300 mg daily in conjunction with adopa-decarboxylase inhibitor (e.g., L-Dopa/carbidopa, L Dopa/carbidopa/entacapone orL-Dopa/benserazide) administered at least 3 times per day for at least 2 weeks priorto the Day 1 Visit.

Exclusion Criteria:

1. Participants with a history or clinical features consistent with essential tremor,atypical or secondary parkinsonian syndrome (including, but not limited to,progressive supranuclear palsy, multiple system atrophy, cortico-basal degeneration,or drug-induced or poststroke parkinsonism).
2. Participants with a history of psychosis or hallucinations within the previous 12months.
3. Participants with epilepsy, or history of epilepsy, or conditions that lower seizurethreshold, seizures of any etiology (including substance or drug withdrawal), or whohave increased risk of seizures as evidenced by history of electroencephalogram withepileptiform activity are excluded. Participants with a history of febrile seizuresonly are allowed with medical monitor approval.
4. History of substance or alcohol-use disorder (excluding nicotine; Diagnostic andStatistical Manual of Mental Disorders, 5th edition criteria) within 2 years prior tosigning the informed consent form (ICF).
5. Participants who answer "Yes" on the C-SSRS Suicidal Ideation Item 4 (Active SuicidalIdeation with Some Intent to Act, Without Specific Plan) and whose most recent episodemeeting criteria for this C-SSRS Item 4 occurred within the last 6 months, ORParticipants who answer "Yes" on the C-SSRS Suicidal Ideation Item 5 (Active SuicidalIdeation with Specific Plan and Intent) and whose most recent episode meeting criteriafor this C-SSRS Item 5 occurred within the last 6 months OR Participants who answer "Yes" on any of the 5 C-SSRS Suicidal Behavior Items (actual attempt, interruptedattempt, aborted attempt, preparatory acts, or behavior) and whose most recent episodemeeting criteria for any of these 5 C-SSRS Suicidal Behavior Items occurred within thelast 2 years, OR Participants who, in the opinion of the investigator, present aserious risk of suicide.
6. Participants who have attempted suicide in the past.
7. Positive result for human immunodeficiency virus (HIV) antibody, hepatitis B surfaceantigen, hepatitis B core antibody, or hepatitis C antibody with detectable viralribonucleic acid (RNA) levels at Screening.
8. Have been diagnosed with symptomatic coronavirus disease (COVID-19) or test positive (i.e., using polymerase chain reaction [PCR] or rapid antigen test) for COVID-19within 30 days prior to signing the ICF.
9. Participants taking strong or moderate cytochrome P450 family 3 subfamily A member 4 (CYP3A4) inducers or inhibitors or who would be likely to require concomitant therapywith CYP3A4 inducers or inhibitors during the trial. NOTE: Other protocol-defined inclusion and exclusion criteria may apply.