Genetic of Chronic Kidney Disease and Gout in New Caledonia

Phase

N/A

Condition

Arthritis And Arthritic Pain (Pediatric)

Nephropathy

Kidney Disease

Treatment

Epidemiological study

Clinical Study ID

NCT05607797

RC-P00116

Ages 18-80
All Genders
Accepts Healthy Volunteers

Study Summary

The goal of this research is to study the associations of genetic variants of gout and kidney failure, which are very common in the Melanesian population in New Caledonia

Eligibility Criteria

Inclusion

Inclusion Criteria:

Criteria common to the 3 cohorts :

Consenting to participate in the study and having signed the informed consent
Claiming to be of Melanesian ethnicity

Patients with gout :

Age: 18 - 70 years old
To be included in the study, a patient with a diagnosis of gout in his medicalfile or declaring to have gout will have to satisfy to the ACR/EULAR (ref)classification criteria :

have had at least one episode of swelling, pain spontaneous, or triggeredby pressure, of a joint peripheral or a bursa AND evidence of sodium uratecrystals in a joint or bursitis symptomatic or by puncture of a tophusreported in his medical file.
Or Score > or =8 according to ACR/EULAR clinical criteria
Patients with CKD

Age: 18 - 70 years old
Patients on dialysis or CKD clinically diagnosed on the basis of:

Markers of kidney damage (one or more) : Albuminuria (ACR ≥ 30 mg/g),Urinary sediment abnormalities (e.g., casts urinary), Electrolyteabnormalities and other, abnormalities due to tubular disorders (eg,hyperkalemia), abnormalities detected by histology, structuralabnormalities detected by imaging (e.g.,USG), history of kidneytransplantation
Decreased kidney function: GFR < 60 ml/min/1.73 m² (calculated accordingto the Chronic Kidney Disease - EPIdemiology formula: CKD-EPI)
Controls cohort

Absence of gout or CKD
Age: 30 - 80 years old

Exclusion

Exclusion Criteria:

Pregnant women
Individuals under guardianship / curatorship / judicially incapacitated

Study Design

Epidemiological study

March 14, 2023

April 30, 2024

Study Description

Gout is a chronic pathology linked to the deposition in the tissues of monosodium urate (MSU) crystals, secondary to hyperuricemia (high blood levels of urate). Gout causes very painful joint attacks that are first acute and then lead to chronic pain, and disabling deforming manifestations called tophus. The disease is strongly associated with cardiovascular comorbidities and chronic renal failure.

In New Caledonia, the prevalence of chronic kidney disease (CKD) (according to the glomerular filtration rate (GFR) < 60 ml/min) was of 7.4% in 2015 (according to the epidemiological study "Barometer Health 2015"). In the Loyalty Islands, which has overall significantly more Melanesian population, a local database showed that in 2018 the prevalence of patients having at least one blood test reporting kidney disease (GFR CKD< 60 ml/min) and seen at least once in the previous two years was as follows:

7.7% in Lifou (9,200 inhabitants)
8.4% in Maré (5,700 inhabitants)
9.1% in Ouvéa (3,400 inhabitants) In summary, inflammatory diseases such as CKD and gout have high prevalence in New Caledonia and the Loyalty Islands, and constitute a major health issue. Although the high prevalence of these diseases is probably due in part to non-genetic factors (environment, diet, etc.), it is likely, given the demographic history of this region, that undetected genetic risk alleles among the Melanesian population contribute to the appearance and progression of diseases. Performing genetic and epidemiological studies in an as yet understudied region is essential to identify these variants, which could lead to improved diagnoses and health outcomes.

Connect with a study center

Medical Center of Wé (Lifou Island)
Nouméa,
New Caledonia
Site Not Available

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