First in Human Study of EMB-07 in Locally Advanced/Metastatic Solid Tumors or Relapse/Refractory Lymphoma

Inclusion Criteria:

1. Willing and able to provide signed and dated informed consent prior to anystudy-related procedures and willing and able to comply with all study procedures.

2. Male or female, and aged ≥ 18 years

3. Treatment group A: Patients with histologically or cytologically locally advancedunresectable or metastatic solid tumors limiting to triple-negative breast cancer,lung adenocarcinoma, ovarian cancer, pancreatic cancer, colorectal cancer, gastriccancer, prostate cancer, bladder cancer, and uterus cancer. Treatment group B:Patients with histologically or cytologically relapse/refractory lymphoma limitingto chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle celllymphoma (MCL) and diffuse large B cell lymphoma (DLBCL).

4. Treatment group A: Standard therapies do not exist, or are no longer effective, orare not tolerable or accessible to the patient measurable or evaluable disease perRECIST V1.1. Treatment group B: Presence of at least one two-dimensional measurablelesion confirmed by imaging (CT or MRI) (either lymph nodes lesions with any longdiameter > 1.5 cm or extranodal lesions with any long diameter > 1.0 cm); for CLLpatients whose baseline imaging evaluation determined that no two-dimensionalmeasurable lesions, their peripheral blood monoclonal B lymphocytes should be ≥ 5.0×109/L.

5. Patients must provide archival tumor samples, or a biopsy will be required ifarchival tumor sample is not available. Archival tumor sample must be taken ≤ 2years prior to screening, otherwise a fresh tumor biopsy at screening is required.

6. ECOG performance status 0 or 1

7. Adequate organ function to participate in the trial.

8. Recovery from adverse events (AEs) related to prior anticancer therapy.

Exclusion Criteria:

1. Prior treatment with any agent targeting ROR1.

2. History of Grade 4 immune-related adverse events (irAEs) or irAEs requiringdiscontinuation of prior therapies.

3. Patient with primary central nervous system (CNS) malignancy or symptomatic CNSmetastases. Patients with solid tumors with CNS metastases are eligible if they donot need to receive local radiation treatment at the discretion of investigator orif radiation therapy for CNS metastases is completed ≥ 4 weeks prior to studytreatment.

4. Anticancer therapy or radiation < 5 half-lives or 4 weeks (whichever is shorter)prior to study treatment.

5. Abuse on alcohol, cannabis-derived products, or other drugs.