PCP in Immunocompromised Population in Southern China

Last updated: November 3, 2022
Sponsor: First Affiliated Hospital of Guangxi Medical University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pneumonia

Treatment

N/A

Clinical Study ID

NCT05605145
GX-PCP-2020
  • All Genders

Study Summary

To evaluate the sensitivity and specificity of the combined detection system for the diagnosis of pneumocystis infection in immunocompromised population in Southern China.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients with immunocompromised conditions, including but not limited to HIVinfection, long-term systemic use of corticosteroids, use of immunosuppressive agents,hematologic malignancies, solid tumors, hematopoietic stem cell transplantation, solidorgan transplantation, radiotherapy and/or chemotherapy for malignancies,primaryimmunodeficiency disease.
  2. Patients with typical clinical manifestations of PJP such as fever,nonproductivecough, shortness of breath, and progressive hypoxemia.
  3. Patients with radiological abnormalities suggestive to PJP in bilateral lungs revealedby chest computed tomography (CT).
  4. Respiratory tract samples were collected for qPCR and/or mNGS detection.

Exclusion

Exclusion Criteria:

  1. Patients who were unable to obtain a respiratory specimen.
  2. Medical record was incomplete.

Study Design

Total Participants: 300
Study Start date:
May 12, 2021
Estimated Completion Date:
June 30, 2023

Study Description

Pneumocystis jirovecii pneumonia (PJP) is a serious opportunistic infection in immunocompromised patients, with a difficult diagnosis, rapid progression and high mortality rate. The PJP mortality rate is high among patients with delayed diagnosis and treatment, and death is due to severe respiratory failure. Up to now, data regarding Pneumocystis jirovecii infection in immunocompromised patients is limited. In the present prospective study, the investigators aimed to evaluate the sensitivity and specificity of the combined detection system for the diagnosis of pneumocystis infection in immunocompromised population in Southern China.

Connect with a study center

  • First Affiliated Hospital of Guangxi Medical University

    Nanning, Guangxi 510515
    China

    Active - Recruiting

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