Global Cardio Oncology Registry

Last updated: October 27, 2022
Sponsor: The Cleveland Clinic
Overall Status: Active - Recruiting

Phase

N/A

Condition

Breast Cancer

Chest Pain

Blood Cancer

Treatment

N/A

Clinical Study ID

NCT05598879
IRB 22-211
  • Ages > 18
  • All Genders

Study Summary

G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increased incidence of cancer therapy related cardiovascular toxicity (CTR-CVT) in different settings and to derive and validate risk scores for cardio oncology patients treated in different geographic locations throughout the world.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • New cardio-oncology consultation for breast cancer patients, or
  • New cardio-oncology consultation for Hodgkin's or non-Hodgkin's lymphoma patients, or
  • New cardio-oncology consultation for acute or chronic leukemia patients, or
  • New cardio-oncology consultation for multiple myeloma or AL amyloidosis, or
  • New cardio-oncology consultations for immune check-point inhibitors cardiacevaluation.
  • All patients have to be 18 years old or older

Exclusion

Exclusion Criteria:

  • Cardio-oncology patients who have previously had cardio-oncology evaluation and followup by the investigators.
  • Minors less than 18 years old.
  • Inability or unwillingness to consent to participate

Study Design

Total Participants: 5000
Study Start date:
July 01, 2022
Estimated Completion Date:
July 01, 2027

Study Description

G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increased incidence of cancer therapy related cardiovascular toxicity (CTR-CVT) in different settings and to derive and validate risk scores for cardio oncology patients treated in different geographic locations throughout the world.

G-COR will involve the collaboration from 124 hospitals from 24 countries that completed survey with sites demographics. It will evaluate cardiovascular disease in three distinct populations of cancer patients (hematological malignancies: lymphomas, leukemias, multiple myeloma; breast cancer patients; and patients treated with check point inhibitors immunotherapy).

G-COR will evaluate the cardiovascular impact of different cancer treatments in the above-described patients, and similarities and differences in diagnostic and treatment modalities as well as outcomes and the impact of socioeconomic factors and risk factors for toxicities in a large worldwide population.

G-COR will study the impact of cancer in CV disease in cancer patients treated at academic centers as well as in patients treated at community hospitals, through a systematic prospective data collection in a global digital platform.

G-COR is an IRB approved prospective registry, conducted with the logistical support of C5 Clinical Research Division and the Cardiovascular Outcomes Registries and Research (CORR) group at the Cleveland Clinic and have developed eCRFs with an extensive Red Cap Cloud platform.

G-COR Executive, Scientific and topic committees are led by North American, European, Latin American, Australian and Asian representatives from both academic and community centers.

The pilot phase of G-COR enrolls breast cancer patients only, and the global phase will include all three cohorts of patients (breast, Hem and ICIs).

The investigators have started enrolling patients for G-COR pilot phase with US centers, and will start the global international phase in 2023.

Connect with a study center

  • Cleveland Clinic Florida

    Weston, Florida 33331
    United States

    Active - Recruiting

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