Effect of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients After Intravenous Thrombolysis (RICCH-IVT)

Inclusion Criteria:

1. age ≥ 18 and < 80 years, both sexes;

2. a clear clinical diagnosis of acute ischemic stroke and treatment with standardrt-PA (0.9 mg/kg) IVT within 4.5 h of stroke onset;

3. pre-onset modified Rankin Scale (mRS) score ≤1;

4. baseline National Institute of Health Stroke Scale (NIHSS) score ≥5 and ≤25;

5. Glasgow Coma Scale score ≥8.

Exclusion Criteria:

1. having received bridging therapy (IVT plus mechanical thrombectomy);

2. previous history of atrial fibrillation or electrocardiographic evidence of atrialfibrillation;

3. contraindications to RIC treatment or previous RIC treatment or similar treatment;

4. pregnancy or breastfeeding;

5. life expectancy of ≤3 months or inability to complete the study for other reasons;

6. unwillingness to be followed up or poor treatment compliance or participation inother clinical studies;

7. had insufficient bilateral temporal bone windows for insonation of the middlecerebral artery.