Quadratus Lumborum Block After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy

Last updated: August 14, 2024
Sponsor: Gangnam Severance Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Malignant Ascites

Fever

Peritoneal Cancer

Treatment

Arm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block)

Clinical Study ID

NCT05597683
3-2022-0328
  • Ages > 19
  • All Genders

Study Summary

This study aims to assess whether transmusculr quadratus lomborum block (QL block) can reduce postoperative pain after cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC). Patients will be randomly assigned to either QL block group or control group. Ultrasound-guided bilateral transmuscular quadratus lomborum block will be performed in QL block group using 0.375% ropivacaine. Multimodal analgesic regimen including acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), and rescue opioids will be used in every patient. Primary outcome is opioid consumption for 24 hours after surgery. Secondary outcomes included pain scores, time to first rescue analgesics, quality of recovery score, length of hospital stay.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients who are scheduled to undergo cytoreductive surgery and hyperthermicintra-peritoneal chemotherapy (CRS and HIPEC)

Exclusion

Exclusion Criteria:

  1. Allergy to local anesthetics or fentanyl

  2. Chronic pain

  3. Drug abuse

  4. Patients who are unable to use patient-controlled analgesia

  5. Skin infection at site for quadratus lomborum block

  6. pregnant or breatfeeding women

  7. Patients who are unable to communicate

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Arm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block)
Phase:
Study Start date:
November 15, 2022
Estimated Completion Date:
January 10, 2025

Study Description

Adult patients scheduled to undergo cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy will be screened for eligibility. After induction of general anesthesia, ultrasound-guided bilateral transmuscular quadratus lomborum block will be done in QL block group. 0.375% ropivacaine will be injected to each side. Patients in control group will receive no block. Multimodal analgesia will be applied to every patient for postoperative pain control. Multimodal analgesic regimen included scheduled administration of acetaminophen, NSAIDs, and rescue opioids. Blinded investigator will assess pain scores at rest and on movement at 6, 12, 24, 48, 72 hours after surgery, analgesic consumptions, nausea, vomiting, and quality of recovery questionnaire.

Connect with a study center

  • Gangnam Severance Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

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