Phase
Condition
Claudication
Occlusions
Deep Vein Thrombosis
Treatment
Anticoagulant Therapy
Catheter-Directed Therapy
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Symptomatic PE diagnosed by contrast-enhanced CT angiography with involvement of amain or lobar pulmonary artery branch; and
Right ventricular (RV) dilation as defined by the presence of an RV/Left ventricularratio > 1 on CT angiography
Exclusion
Exclusion Criteria:
Age < 18 years
Systolic blood pressure < 90 mmHg for >15 consecutive minutes or > 40 mmHg drop frombaseline, or vasopressor requirement for blood pressure support (i.e., massive PE),occurring within 1 hour prior to eligibility assessment.
Symptom duration > 14 days for the current PE episode
Irreversible INR > 3
Irreversible Thrombocytopenia (Platelets < 50,000/microliter)
Creatinine > 2.0 mg/dl
Hemoglobin < 7.0 g/dl
Pregnancy (positive urine or blood pregnancy test (a pregnancy test must be obtainedwithin 7 days prior to randomization in people of childbearing potential))
Allergy or hypersensitivity to Recombinant Tissue Plasminogen Activator (rt-PA), oriodinated contrast, except for mild-moderate contrast allergies for which steroidpre-medication can be used
Life expectancy < 1 year
Chronic inability to independently walk prior to the current PE episode (e.g.wheelchair dependent, walker or cane dependent, paraplegic, and/or bed-bound)
Allergy to heparin or history of Heparin-Induced Thrombocytopenia (HIT)
Unable or unwilling to provide informed consent
Major contraindication or unsuitability for all CDT methods available at theClinical Center
Study Design
Connect with a study center
The University of Alabama At Birmingham
Birmingham, Alabama 35233
United StatesActive - Recruiting
Cedars-Sinai Medical Center
Los Angeles, California 90048
United StatesSite Not Available
Stanford Medicine
Palo Alto, California 94304
United StatesActive - Recruiting
UC Davis Health
Sacramento, California 95817
United StatesActive - Recruiting
Scripps Memorial Hospital, La Jolla
San Diego, California 92121
United StatesActive - Recruiting
The Lundquist Institute
Torrance, California 90502
United StatesActive - Recruiting
Christiana Care
Newark, Delaware 19718
United StatesActive - Recruiting
Christiana Care Health System
Newark, Delaware 19713
United StatesActive - Recruiting
MedStar Health Research Institute
Washington, District of Columbia 20010
United StatesActive - Recruiting
Baptist Health Miami Cardiac & Vascular Institute
Miami, Florida 33176
United StatesActive - Recruiting
Baptist Hospital of Miami
Miami, Florida 33143
United StatesActive - Recruiting
University of South Florida/ Tampa General Hospital
Tampa, Florida 33606
United StatesActive - Recruiting
Emory University
Atlanta, Georgia 30322
United StatesActive - Recruiting
Emory University School of Medicine
Atlanta, Georgia 30308
United StatesActive - Recruiting
University of Chicago Medical Center
Chicago, Illinois 60637
United StatesActive - Recruiting
Advocate Aurora Health
Downers Grove, Illinois 60515
United StatesActive - Recruiting
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
United StatesActive - Recruiting
Loyola University Chicago
Maywood, Illinois 60153
United StatesActive - Recruiting
Southern Illinois University School of Medicine
Springfield, Illinois 62781
United StatesActive - Recruiting
University of Iowa
Iowa City, Iowa 52242
United StatesActive - Recruiting
MaineHealth
Portland, Maine 04102
United StatesActive - Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
United StatesActive - Recruiting
Boston Medical Center
Boston, Massachusetts 02118
United StatesActive - Recruiting
University of Michigan
Ann Arbor, Michigan 48109
United StatesActive - Recruiting
Trinity Health - Ann Arbor Hospital
Ypsilanti, Michigan 48197
United StatesActive - Recruiting
Washington University in St. Louis
Saint Louis, Missouri 63110
United StatesActive - Recruiting
Rutgers New Jersey Medical School
Newark, New Jersey 07103
United StatesActive - Recruiting
University of New Mexico Health Sciences Center
Albuquerque, New Mexico 87131
United StatesActive - Recruiting
Columbia University
New York, New York 10027
United StatesSite Not Available
Icahn School of Medicine at Mount Sinai
New York, New York 10029
United StatesActive - Recruiting
NYU Langone Health - Tisch Hospital
New York, New York 10016
United StatesActive - Recruiting
Weill Cornell Medicine
New York, New York 10065
United StatesActive - Recruiting
Cone Health
Greensboro, North Carolina 27403
United StatesSite Not Available
Promedica
Toledo, Ohio 43606
United StatesActive - Recruiting
Oregon Health & Science University
Portland, Oregon 97239
United StatesActive - Recruiting
Thomas Jefferson University
Philadelphia, Pennsylvania 19107
United StatesActive - Recruiting
University of Pennsylvania
Philadelphia, Pennsylvania 19104
United StatesActive - Recruiting
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania 15232
United StatesActive - Recruiting
Main Line Healh
Wynnewood, Pennsylvania 19096
United StatesActive - Recruiting
Lifespan
Providence, Rhode Island 02903
United StatesActive - Recruiting
Medical University of South Carolina
Charleston, South Carolina 29425
United StatesActive - Recruiting
The University of Texas Health Science Center at Houston
Houston, Texas 77030
United StatesActive - Recruiting
Intermountain Health
Murray, Utah 84107
United StatesActive - Recruiting
University of Utah Health
Salt Lake City, Utah 84108
United StatesActive - Recruiting
Sentara Health Research Center
Norfolk, Virginia 23507
United StatesActive - Recruiting
Carilion Clinic
Roanoke, Virginia 24014
United StatesActive - Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United StatesActive - Recruiting
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