Effect of PreforPro® on Urinary and Vaginal Health

Inclusion Criteria:

• Female
• 18-45 years old premenopausal (period within 6 months)
• Nugent score of 4-6 (intermediate) or 7-10 (BV)
• Have an ability to collect a clean urine sample
• Prescription and over the counter medication unchanged for > 30 days prior to thestudy. -Participants who are taking medications as needed (PRN) may be included ifthey began PRN usage >30 days prior to baseline
• Sexually active status of the participants can be either active or inactive
• Participants must agree to use a medically approved method of birth control (e.g.hormonal contraceptives, intrauterine devices, vasectomy/tubal ligation, barriermethods and double-barrier method) and must have negative pregnancy test results atscreening and baseline

Exclusion Criteria:

• Faecal incontinence
• History of urinary fistula, bladder or kidney stones, interstitial cystitis, orcystoscopic abnormalities that could be malignant
• Neurogenic bladder
• A history of currently undergoing immunosuppressive drug therapy, chemotherapy, orradiation therapy
• Antibiotic and/or anti-fungal medication used within the last four weeks
• Oral probiotic supplement use within 2 weeks prior the study excluding yogurt
• Drug abuse
• Uncontrolled psychological disorders