Effect of Preoperative High-dose Cholecalciferol in Prevention of Post-thyroidectomy Hypocalcaemia

Last updated: March 27, 2023
Sponsor: Pak Emirates Military Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hypoparathyroidism

Parathyroid Disorders

Treatment

N/A

Clinical Study ID

NCT05586529
Thy 1 cpsp
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Hypocalcaemia after thyroidectomy is observed with increasing frequency, often resulting in prolonged hospital stay with increased use of resources, delayed return to work and reduced quality of life. The administration of vitamin D is essential in the therapy of postoperative hypocalcaemia. What has not been examined so far is whether and how routine preoperative cholecalciferol prophylaxis can help to prevent postoperative hypocalcaemia

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients (> 18 years)
  • Scheduled for TT
  • Thyroid cancer treated with total thyroidectomy without lymph node dissection

Exclusion

Exclusion Criteria:

  • Lack of written consent
  • Thyroid cancer treated with TT and lymph node dissection
  • Mediastinal goiter with need for sternotomy
  • Medication with thiazide diuretics, digitalis or lithium therapy
  • Previous neck operations or radiation
  • Preexisting hyperparathyroidism
  • Chronic kidney failure.

Study Design

Total Participants: 170
Study Start date:
November 01, 2022
Estimated Completion Date:
December 31, 2024

Study Description

Hypocalcemia following thyroid surgery is caused either due to parathyroid devascularization, stunning, or accidental removal of the parathyroid glandsMultiple risk factors have been identified which predispose patients to develop post-operative hypocalcemia. In light of the available evidence of prevalent vitamin D deficiency in the general population, and the observation of appearance of postthyroidectomy hypocalcemic symptoms at a much earlier stage than documented in previous literature, we postulate that a prophylactic vitamin D supplementation dose given in immediate preoperative period can significantly reduce acute symptomatic postoperative hypocalcemia in patients undergoing thyroid surgery

Connect with a study center

  • Pak-Emirates Military Hospital

    Rawalpindi, Punjab
    Pakistan

    Active - Recruiting

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