A Prospective Study of Conventional Bone Marrow Biopsy Versus Portomar(TM) Biopsy

Inclusion Criteria:

• • Patients with a previous bone marrow disorder diagnosis who will require multiplebone marrow biopsies over the course of their treatment, for example patients withplasma cell dyscrasia or leukemia.
• Men and non-pregnant women of age ≥ 21 years with ECOG performance status ≤ 2.
• Any hematologic (platelets above 50, ANC > 1.0, hemoglobin > 7), renal (patientsnot on dialysis), or hepatic (patients with bilirubin below 2.5) function statussuitable to undergo port implantation and subsequent bone marrow biopsies.
• Patients must be able to understand and be willing to sign a voluntary informedconsent form and agree to compliance with the protocol schedule; with theknowledge that they may withdraw consent at any time without impact on futuremedical care.

Exclusion Criteria:

• • Patients with any other ongoing, concomitant, comorbid illness including but notlimited to uncontrolled diabetes, NYHA class III or worse heart failure, uncontrolledcoronary artery disease/arrhythmia.
• Patients unable to comply with the study schema.
• Confirmed pregnancy at time of screening or on implantation day prior toanesthesia/sedation.
• Patients unable to come off of anticoagulation medications for their procedure.
• Patients with active infection.
• Patients with < 0.5 cm or > 2.5 cm of soft tissue between screw head and skin atthe target site of implantation. This is based on the patient's prior imagingstudies (i.e. CT/MR or ultrasound imaging).
• Patient has contra-indication to conscious sedation or anesthesia services
• Patients who have had prior bone marrow biopsy within 2 weeks of the studybiopsy.
• Patients with coagulopathy such that INR cannot be corrected < 2.0.
• Patients who are prisoners or wards of the court.
• Patients with alcohol or substance abuse disorder defined by DSM V criteria.
• Patients with the diagnosis of a major psychiatric disorder such as schizophreniaor major depression defined by the DSM-V criteria.
• Patients with osteoporosis defined as L1 vertebrae bone density lower than 90Hounsfield units