Combined Phacoemulsification With iStent Inject W Versus Hydrus for Mild to Moderate Open Angle Glaucoma

Inclusion Criteria:

• >60 years or older

• Visually significant cataract

• Mild to moderate primary open angle glaucoma controlled on medications

• undergoing cataract surgery with lens implantation and concurrent microstentplacement

• IOP ≥ 21 mmHg and ≤ 36 mmHg after washout of ocular hypotensive medication(s)

• CCT 480 to 620μm

• No prior ocular surgery including corneal refractive surgery

• No SLT within 6 months of baseline visit, no history of intracameral glaucoma drugeluting implants

• Visual field mean deviation ≤ -12 dB

• Optic nerve abnormalities consistent with glaucoma, C/D ratio less than ≤0.8

Exclusion Criteria:

• Prior intraocular surgery

• Visual field MD ≥ -12 dB

• secondary glaucoma including uveitis, traumatic, malignant, neovascular, andcongenital glaucoma.

• Glaucoma related to elevated episcleral venous pressure including Sturge-Webersyndrome, thyroid eye disease, orbital tumor, and etc.

• Uncontrolled intraocular pressure on maximum tolerated medical therapy;

• Unable to perform wash-out IOP

• Anatomic exclusion of narrow anterior chamber angle (Shaffer grade I-II), otherangle abnormalities including angle closure glaucoma

• Corneal disease or dystrophy

• Pathological myopia with degeneration that affects diagnostic imaging

• Clinically significant ocular pathology or degenerative diseases that affect vision,visual field, or optical coherence tomography of optic nerve.

• Inability to perform reliable Visual Field and optical coherence tomography.