Lactate Metabolism in the Hypoperfused Critically Ill

Last updated: October 12, 2022
Sponsor: University of Copenhagen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cerebral Ischemia

Low Blood Pressure (Hypotension)

Distal Renal Tubular Acidosis

Treatment

N/A

Clinical Study ID

NCT05582824
LacMeta
  • Ages > 18
  • All Genders

Study Summary

Investigating lactate metabolism in critically ill patients whom are hypoperfused by preforming metabolomics via liquid chromatography-mass spectrometry.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed with sepsis/septic shock or severe heart failure.
  • Clinical and paraclinical signs of hypoperfusion in relation to abovementioneddiagnosis.
  • Metabolic acidosis with s-lactate equal-to-or-above 4 mmol/l.
  • Incapacitated

Exclusion

Exclusion Criteria:

  • Only regional hypoperfusion such as a leg.
  • Receiving intravenous lactate as part of treatment.
  • Going in to dialysis. The exclusion is only during dialysis treatment.

Study Design

Total Participants: 20
Study Start date:
September 15, 2022
Estimated Completion Date:
January 31, 2023

Study Description

Lactate concentration is well known to be directly correlated with risk of death during admission to intensive care. However, lactate by itself is not considered toxic. The study is observational. The breakdown of lactate is being investigated by collecting blood- and urinsamples from patients with hyperlactatemia as a result of hypoperfusion. Levels of lactate, and known as well as unknown metabolites will be identified and quantified by metabolomics. Metabolomics is performed using a combination of liquid chromatography and mass spectrometry. Data will be analysed via statistical analysis to investigate corelations between lactate, a given metabolite and hard outcome such as mortality. And thereby lay the groundwork for potential further research regarding specific lactate-metabolites.

Connect with a study center

  • Hvidovre University Hospital

    Hvidovre, Hovedstaden 2650
    Denmark

    Active - Recruiting

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