Immune Response of Shingrix Vaccine in People Living With HIV (> 50 y.o.) Compared to Age-matched Controls

Inclusion Criteria:

For PLWH:

• Be registered in the SHCS or in the ANRS CO3 Aquitaine Cohort

• Age >50 YOA

• Time since cART initiation > 10 years

• Not already vaccinated with RZV

• HIV viral load <50 copies/ml (within 6 months from the last blood sampling)

• Informed consent as documented by signature

• (France) : Person affiliated with or beneficiary of the French social securityscheme

For aged/gender-matched controls

• Age >50 YOA

• Not already vaccinated with RZV

• Informed consent as documented by signature

• (France) Not HIV infected

• (France) Person affiliated with or beneficiary of the French social security scheme

Exclusion Criteria:

• Ongoing signs of febrile or non-febrile infection at the time of the firstvaccination

• Immunosuppression from the following:

• Current malignant neoplasm;

• primary immunodeficiency;

• recent (<2 years) solid or bone-marrow transplant or any transplant stillrequiring immunosuppressive therapy

• Intake of drugs which suppress the immune system (e.g. glucocorticoids for a longtime [an equivalent dose of prednisolone >20 mg/day > 3 months], monoclonalantibodies, cytostatics, biological products, etc.) within 6 months beforescreening.

• Administration of immunoglobulins or any blood products within 3 months precedingthe first dose of vaccine or planned administration during the study period

• Having received a vaccine in the last month or is expected to receive a vaccine inthe next month

• Having received a shingles vaccine within one year

• Presented with herpes zoster in the previous year

• Contra-indication to RZV

• Hospitalized patients

• Unable to provide informed consent or inability to follow the procedures of thestudy, e.g. due to language problems, psychological disorders, dementia, etc. of theparticipant

• Participation in another study with investigational drug within the 30 dayspreceding and during the present study.

• (France) Pregnant or breastfeeding woman

• (France) Patient governed by articles L 1121-5 to L 1121-8 (persons deprived oftheir liberty by a judicial or administrative decision, minors, persons of legal agewho are the object of a legal protection measure or unable to express their consent)