Behavioral Activation and Medication Optimization In Older Adults Undergoing Cardiac Procedures

Last updated: October 22, 2025
Sponsor: Washington University School of Medicine
Overall Status: Completed

Phase

N/A

Condition

Cardiac Surgery

Anxiety Disorders

Depression

Treatment

Care as usual

Behavioral activation

Medication optimzation

Clinical Study ID

NCT05575128
202209033
P50MH122351
  • Ages > 60
  • All Genders

Study Summary

This Hybrid 1 Study will test the effectiveness of a bundled intervention comprised of behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing cardiac surgery (compared with usual care), while examining implementation outcomes.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Adults ≥ 60 years

  • Scheduled major cardiac procedure

  • PHQ-ADS ≥ 10, indicating clinically significant depression or anxiety symptoms

Exclusion

Exclusion criteria:

  • Barrier to communication (Unable to read, speak, and understand English)

  • Severe cognitive impairment screened by the SBT (Short Blessed Test) >10

  • Acutely suicidal

  • Previous participation in this study or CPMH feasibility study 202101103.

Study Design

Total Participants: 102
Treatment Group(s): 3
Primary Treatment: Care as usual
Phase:
Study Start date:
November 05, 2022
Estimated Completion Date:
March 29, 2025

Connect with a study center

  • Washington University in St. Louis

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Washington University in St. Louis

    St Louis 4407066, Missouri 4398678 63110
    United States

    Site Not Available

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