Home Rehabilitation After Acute Pulmonary Embolism

Last updated: March 4, 2025
Sponsor: University of Rochester
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Lung Injury

Deep Vein Thrombosis

Chest Pain

Treatment

Daily Activity Text

Control Text

Clinical Study ID

NCT05571189
STUDY00007680
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to evaluate whether a home rehabilitation program after hospitalization for acute pulmonary embolism (PE) improves clinical outcomes at 3 months compared to usual care. Daily physical activity tasks that incorporate heart rate monitoring will be sent through email or text. This information could help improve the management of acute PE.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • English speaking (>18 years old). Daily messages will be sent in English.

  • Acute PE with right ventricular enlargement or dysfunction defined by echocardiogramreport, CT Angiogram report, or elevated cardiac biomarker (NT-pro BNP or troponin).

  • Baseline testing started within 7 days of hospital discharge.

Exclusion

Exclusion Criteria:

  • Pregnancy.

  • Cardiac Effort >2.5 beats/m during 6MWT. This is for safety.

  • Cardiac Effort <1.2 beats/m during 6MWT. They are unlikely to benefit.

  • Resting tachycardia >120 beats/m during screening or at hospital discharge.

  • Suspicion for Chronic Thromboembolic Pulmonary Hypertension.

  • Systolic blood pressure >180 mmHg during screening or at hospital discharge.

  • Inability to walk.

  • Estimated prognosis <12 months at the time of discharge due to underlyingco-morbidities.

  • Advanced neurologic disease.

  • Lack of access to email or text messaging.

  • Inability to follow daily instructions.

  • Participation in a structured exercise routine at least three days per week in theprior four weeks.

  • Principal Investigator discretion

Study Design

Total Participants: 80
Treatment Group(s): 2
Primary Treatment: Daily Activity Text
Phase:
Study Start date:
December 19, 2022
Estimated Completion Date:
June 01, 2026

Connect with a study center

  • University of Rochester Medical Center

    Rochester, New York 14642
    United States

    Site Not Available

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