Zip-Stitch® in Minimally-Invasive Surgery (ZIMS) - Safety & Efficacy in Hysterectomy

Inclusion Criteria:

1. Provision of signed and dated Informed Consent Form 2. Stated willingness to complywith all study procedures, including participation in follow-up visits andtelephonic follow-up 3. Female 18 years and older 5. Indicated for LaparoscopicHysterectomy (includes Total Laparoscopic Hysterectomy, Laparoscopic AssistedVaginal Hysterectomy, or robotic assisted vaginal hysterectomy)

Exclusion Criteria:

1. History of Human Immunodeficiency Virus (HIV)

2. History of Hepatitis C

3. History of diabetes that, in the opinion of the investigator, may delay healing

4. Current use of systemic corticosteroids

5. Active infection of genitals, vagina, cervix, uterus or urinary tract

6. Active bacteremia, sepsis or other active systemic infection

7. Presence of Sexually Transmitted Infection (STI)

8. Evidence of pelvic inflammatory disease (PID)

9. Known clotting defects or bleeding disorders

10. Hemoglobin < 8 g/dL

11. Metastatic disease

12. On anticoagulant therapy

13. Participation in another interventional trial

14. Pregnancy

15. Abnormal Papanicolaou test (PAP) results that have not been fully evaluated, or inthe opinion of the investigator may indicate abnormal vaginal cuff healing

16. Co-morbidities that, in the opinion of the investigator, may indicate risk ofabnormal vaginal cuff healing

17. Intra-operative: Bowel injury during laparoscopic hysterectomy procedure prior toattempted cuff closure

18. Intra-operative: Bladder injury during laparoscopic hysterectomy procedure prior toattempted cuff closure

19. Intra-operative: Cases in which surgeon cannot identify adequate tissue along thecuff to apply suture laparoscopically

20. Intra-operative: Cases requiring conversion to laparotomy prior to studyintervention