A Study of EDP-938 in Non-hospitalized Adults With RSV Who Are at High Risk for Complications.

Inclusion Criteria:

• At least one of the following conditions that predispose them to complications afterRSV infection:

1. Age ≥65 years

2. Congestive heart failure (CHF)

3. Asthma

4. Chronic obstructive pulmonary disease (COPD)

• The subject has a new onset of any of the following symptom(s) or worsening ofpre-existing symptom(s) consistent with a respiratory tract infection no more than 72 hours prior to the administration of the first dose of study drug: feelingfeverish, headache, neck pain, fatigue, loss of appetite, interrupted sleep, bodyaches, sore throat, nasal congestion, cough, cough with phlegm, wheezing, or shortof breath.

• The subject reports at least 2 of the following symptoms, one of which must bereported as at least 'moderate' severity: cough, cough with phlegm, wheezing, orshort of breath

• The subject has tested positive for RSV infection using a NAAT (polymerase chainreaction [PCR] or other) on a nasal/nasopharyngeal swab sample.

• A woman of childbearing potential who is sexually active with a male must agree touse two effective methods of contraception from the date of Screening until 30 daysafter her last dose of study drug.

• A male subject who has not had a vasectomy and is sexually active with a woman ofchildbearing potential must agree to use effective contraception from the date ofScreening to 90 days after his last dose of study drug.

Exclusion Criteria:

• The subject has an anticipated need for hospitalization within 24 hours of signingthe Study ICF

• The subject receives systemic antiviral, antibacterial, antifungal, orantimycobacterial therapy within 7 days prior to signing the Study ICF

• The subject has concomitant respiratory infections that are viral (other than RSVbut including influenza), bacterial, or fungal, including systemic bacterial orfungal infections, within 7 days prior to signing the Study ICF

• The subject has a SARS-CoV-2 test result that is positive within 28 days prior tosigning the Study ICF

• The subject has COPD with spirometry results (obtained within 1 year prior tosigning the Study ICF) FEV1 ≤35%

• The subject has a known positive human immunodeficiency virus infection, activehepatitis A virus infection, chronic hepatitis B virus infection, and/or currenthepatitis C virus (HCV) infection; subjects with a history of HCV infection who haveachieved a documented sustained virologic response 12 weeks after completion of HCVtherapy may be enrolled.

• The subject has any of the following cardiac conditions: any congenital heartdisease, congenital long QT syndrome, or any clinical manifestation resulting in QTinterval prolongation

• The subject has immunocompromised status

• The subject is living in institutional care or assisted living facility and is alsoreceiving acute care management for any respiratory condition; Note: Independentliving apartments are not considered institutional care or assisted living facility