A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body

Key Inclusion Criteria:

• Capable of giving signed informed consent which is in compliance with therequirements and restrictions listed in the informed consent form (ICF) and inprotocol.

• Histologically confirmed diagnosis of locally advanced unresectable or metastaticgastric, GEJ, or esophageal adenocarcinoma.

• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

• At least one measurable target lesion per Response Evaluation Criteria in SolidTumors (RECIST) v1.1.

Key Exclusion Criteria:

• Underlying medical or psychiatric conditions that, in the investigator's orsponsor's opinion, will make the administration of study-specified therapyhazardous, including but not limited to:

• Interstitial lung disease, including history of interstitial lung disease ornon-infectious pneumonitis. Active viral, bacterial, or fungal infections requiringparenteral treatment within 14 days of randomization.

• Clinically significant cardiovascular disease, such as New York Heart AssociationClass II or greater cardiac disease or cerebrovascular accident within 3 monthsprior to randomization, unstable angina, or new onset angina within 3 months priorto randomization, myocardial infarction within 6 months prior to randomization, orunstable arrhythmia within 3 months prior to randomization.

• History of prior solid-organ transplantation, including allogenic bone marrowtransplantation.

• Dementia, psychiatric, or substance abuse disorders that would interfere withsatisfying the requirements of the trial.

• Known human epidermal growth factor receptor 2 (HER-2) positive tumor.

• Known untreated, symptomatic, or actively progressing central nervous system (CNS) (brain) metastases. Participants with leptomeningeal metastases are excluded fromenrollment.

• Received prior systemic treatment for locally advanced unresectable or metastaticgastric, GEJ, or esophageal adenocarcinoma.

• Disease progression within 6 months of completion of neoadjuvant or adjuvanttherapy.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.